Peptides sit at an uncomfortable intersection: biologically fascinating, commercially amplified, and often ahead of high-quality human evidence. This article draws from Thomas DeLauer and keeps the focus on what can be practiced with clarity, caution, and respect for the evidence.
Transcript sourced from the original YouTube captions. Timestamps link directly to the video.
And BBC increases the prevalence of growth hormone receptors on those fibiberblasts. And that's that's very important to understand because that's going to be a factor with these secrets and doing a better job of the recovery repair aspects and also keeping these fibroblasts in the right phase changes that they go through in inflammation and recovery and repair. Dr. William Seeds, you are the man when it comes down to muscle building peptides, fat loss peptides. I want to really double click on muscle building peptides in this episode with you since I've got you here. I mean, it's people talk about BPC57 from a recovery aspect. I've always looked at it a little bit more like just from a like muscle building recovery versus injury, but I know it kind of encompasses all of that. What are some of the key muscle building peptides? And then let's break them down individually. Uh I I think we could just we could talk about just the basics of building a foundation um of muscle building with just the secrets the GHR's GRPS the BPC 157 and if we could talk about the IGF IGF-1 that I think we could do a lot with that. Okay. So with with BPC, I want to open with that because I find that that is the that's the compound that people really get interested in first in my opinion and like in my sphere at least like people are open to that when maybe they have a nagging injury or something like that. They're like, "Okay, I'm going to do a round of BPC." Uh but how does that work also for muscle building? Like can you
also for muscle building? Like can you kind of give us the overhead aerial view of that? Sure. After today's video, I put a link down below for Element Electrolytes. And now, in case you haven't seen it, they have their sparkling electrolytes, like an actual can, a readyto drink can of electrolytes in a sparkling fashion. So, it tastes like a soda, but you're getting the electrolyte effect. So, if you're in a caloric deficit, you're trying to cut or you're trying to build muscle but stay lean at the same time, these things are amazing because you can sip on them during your workout and it feels like you're sipping on a soda, but you can also sip on it throughout the day and it just tastes really good. but they still have the same 1, 00 milligrams of sodium, 200 milligrams potassium, and 60 milligrams magnesium. Totally fasting friendly. They won't break a fast. You could have them before your fasted workout. They also have their regular packs, which of course I still use all the time. Like that's my baseline. Anyway, that link down below gets you a free variety pack with any purchase. So, free variety pack. All you got to do is make a purchase and you get a sample variety, excuse me, a sample variety pack with each flavor. So, you got like a citrus salt, which is like lemon lime. You've got a watermelon salt. You've got a grapefruit salt. All these really good flavors. So that link, go to drinklntt. com / thomas. drinklnt. com / toomas. It's in the top line of this description. Make sure you check out their sparkling flavors. Well, I think people have to look at their training as far as where is the most important aspect of muscle building. What's the timing that's most important there? Is it the training aspect or is it the repair recovery?
or is it the repair recovery? If I'm working on making any gains in anything I do, working out or any performance aspect, it's always going to be recovery and repair. And so that's where you got to look at this peptide as a recovery repair type of peptide. It and it's a modulator. It's not it knows in the environment it's in. It it knows how to take advantage of improving that environment. So, we can just talk about a couple of the basics with um what with BPC as far as it's uh where I'm using it for recovery and repair. I'm typically using it with a secret number one because the um fibroblasts that are very important in in recovery and repair and rebuilding receptors and BBC increases the prevalence of growth hormone receptors on those fibroblasts and that's that's very important to understand because that's going to be a factor with these secretogs in doing a better job of the recovery repair aspects and also alo keeping these fibroblasts in the right phase changes that they go through in inflammation and recovery and repair. Um the other aspect of BPC 157 is is you know every is the ability to encourage angioenesis into muscle um in a hypoxic
angioenesis into muscle um in a hypoxic state. So, you know, during exercise, the muscle gets more hypoxic. Um and and that'll bring up that'll bring another point up very that I can bring up here in a little bit. But uh there has u there's a um uh there's something called a hypoxic inducing factor 1 alpha which is very important also in uh in inducing angioenesis but also very important in uh in it in degrading it because it can stop recovery repair. It can stop muscle building. It's actually this very very important um uh signaling agent to know about when you're aging, when you're training because it it reres havoc on on injuries. So BBC 157 helps to some degree indirectly um mitigate that issue with hypoxy inducing factor of of just setting the environment of getting uh blood to the muscle. Um also improves nitric oxide production. Um and that's typically more so there's what's nice about um so there's different types of nitric oxide. There's endothelial nitric oxide, there's neuronal nitric oxide, and there's inducible nitric oxide.
inducible nitric oxide. BPC-157 can encourage um uh uh endothelial nitric oxide production uh which helps in vasodiltation and that angioenous aspect of getting blood to the muscle. The other interesting thing is this neuronal nitric oxide which is very important for muscle contraction um and muscle efficiency and actually that's one area you could say that um BPC plays a little bit of a role when you are training in in improving muscle contraction because it it improves neuronal nitric oxide which is something we could talk about at some point too. Um the other so that that's just a broad aspect there of the nitric oxide production. Um and it reduces so it's a modulator. So it works on endothelial works on neuronal but inducible nitric oxide is something you don't want a lot of. That's an immune type of nitric oxide. You want it at the beginning of inflamm. So when everybody goes through injury repair um recovery, you need inflammation, you need reactive oxygen species, you need things to to make the cells adapt to that challenge and rebuild, right? So you need things like inducible nitric oxide, which can be a
inducible nitric oxide, which can be a signaling agent that creates that starts that environment, but you need to turn it off, too. So BPC 157 can turn off inducible nitric oxide which is really cool. Um and then uh I think what's the the more fascinating aspects of BPC 157 is on the extracellular matrix aspects of of the cell and and outside the cell of setting the environment for everything to be right. And what is that? Well, that's this this uh what's called the uh uh folk poxylin um uh uh activation which is uh it's all about actin making uh uh creating uh and rebuilding factin which are these actin filaments that are very important in connecting the cell to the extracellular matrix. So imagine the cell breaks down and the matrix that the cells are in. They all kind of break apart. Well, they have to all come back together. And this is the crucial part. And you you I you probably haven't even heard about this and I'm sure no one's talked about this outside of at least what we teach the our physicians in in this area is that this is a vital part of rebuilding of the matrix of the cell and the extracellular matrix of
the cell and the extracellular matrix of connecting them. And that's where the actin comes into play and it attaches to an endocrine. And the endocrine connects then to collagen and all these things in the extracellular matrix to make that strong and viable and um and so that is a that's really important to understand that and and I could I shouldn't but I got to kind of jump to another step here. uh I don't want to confuse people but this is where like thymosin beta 4 from the repair side it works on the gactin so imagine a uh how do I how could I make this uh the imagine a uh a tank how it has the the long uh the the track that goes around that's kind of how actin is building it's like pulling up it's building its its length with BPC and TB4. Just imagine fact and Gactin of of how monomers are being pulled away and then it's being rebuilt into these strings. So together they're incredible in that recovery repair aspect. Then thusin beta 4 has these aspects of how it works with collagen in the extracellular matrix and some other aspects of the extracellular matrix of how it all makes it stronger and decreases the fiberblasts activation
decreases the fiberblasts activation into overdoing it over making too creating fibrosis or the things you don't want after an injury. You want parallel collagen formation. you want it anatomical, right? So, that's kind of where I could just pull that in for a second to just talk about that with BPC 157. So, those are just some um those are some highlights I think that are important that I think people should should really understand that it's a and so what does that do? Uh it also upregulates um VEGF um receptors um which which are important um in the propagation of new uh uh new vascule and that angioenesis part. Um and so what it does is by doing all that it it accelerates recovery and repair. It not only makes it better, but it accelerates it. So you can actually if you know how to use these and time them correctly um you can train harder and that's where it becomes a performance I think the performance-enhancing thing because you can do your training can be more significant than it was before because
significant than it was before because you get hurt or you overdo it or you just that the tissue couldn't rebuild the way it needed to. Uh I I believe that's the power of the BPC but also alongside of the secrets. Um I think that's where the power comes. Yeah. I had no idea about the extracellular matrix piece. So I mean oh that's huge. I mean in theory I guess that would help with the um fusion of the satellite cell and ultimately with muscle growth too because you're creating this more favorable environ. Yeah that's where the fun comes. So okay so to close the loop on the BPC157 piece it's obviously a lot more than just the angioenesis but one question that I have is if if you're increasing vascule VEF and more angioenesis more just blood vessels in a given area is that there to stay I mean if you used that used a round of BBC57 or you know you had that angioenesis and then you continued to train at the same intensity and you kept it up does that vasculature remain or I mean that's permanent gain so to speak. Well, it is. I mean, let's go. So, any gain in exercise, especially with strength training, um resistance exercise, um you keep those gains. I mean, they all these things still happen with strength training to some degree, but if you stop, what happens? You lose those gains. I mean, you're going to lose some of that vascular. you're going to lose some of the, you know, the more inactive you are, you're going to build
inactive you are, you're going to build more fibroic tissue over time because everything's continuing to um everything's cells are continuing to change. They're continuing to divide. They go through their cycles. So BPC while you're doing that will maintain that. If you stop the BPC, um will you maintain that extra angioenesis that you've to muscle? Um, I don't know the answer to that. Yeah, that's a great answer. That's a great thought, but I tend to think it has to be um I'm I'm going to tell you it's the same as training. I I think it's something that has to be a constant stimulus to to some degree. You'll keep it to some degree, but not at where it could be if you're utilizing it. and and that's uh I mean the the beautiful thing on BPC is that it's uh it's something that you don't desensitize receptors. There's no problem with tolerance. It's BPC you can use and use it continuously. It's you never have to uh it's not something you have to cycle in and out. What about some of these you know you're seeing more and more like oral versions of it. I mean, is that the oral version specific for gut lining repair or do they have crossover into some of the uh the other areas as well? Yeah, that's always been a great question. And my response to that, I'm going to base it on clinical practice
going to base it on clinical practice and give you my clinical experience of using that. And I'm going to tell you for if you're working on the gut and maybe some other immune issues, uh BPC is I I think that may be a preference. Okay. But if you're doing anything else um of muscle recovery repair or injury repair um I believe I see better results with the injectable and also and even more specifically if there's an injury and I go to the site of the injury it works better. Yeah. Um, and uh I'm not saying that oral can't work because I you have people that I have many people that use oral for the purpose of recovery repair with a secret gossen working out. I just feel you can I I just think you get better results if you're injecting it. Yeah. Would you say that if someone What is the perfect use case for BPC157 from an injury standpoint? Is it more connective tissue or to be more like muscular repair like is it because you mentioned fibiberblast you've mentioned this I know TB4 has some connective tissue properties to it but is it uh or is it all kind of equal is what equal is in terms of BPC57 its particular use case like is it better so if someone has a you know full tendon rupture or something like that versus maybe a muscle belly tear um you know given its affinity for fibiberblast kind
given its affinity for fibiberblast kind of how that works particularly with connective tissue does it work equally for both in your experience or is it better for one or the other? Um I I think it's both. I I think number one you right away you want to mitigate fibrosis and that's always a problem with any muscle injury. So the sooner you can start using BPC, you're going to make a difference for definitely it just stopping a process that could could really hamper it could really make it more difficult um for that muscle to you're not going to get perfect muscle back with a rupture. It just depends on the type of injury this the grade of the the tear. Yeah. Um, but if you have like a complete, let's say you have a complete tendon tear, that's not going to fix anything. It's not going to fix the tendon. Like people who say, "I had a rotator cuff injury and I used BPC 157 and TV4 and all this and I repaired my rotator cuff. It was torn." That's bull. That doesn't work like that. Yeah. It doesn't reattach it magically. No, it doesn't. But if you have interstatial tears um and interstitial tears of tendons are always a problem you know that's what chronic tendinitis is it's so interstitial tears have like fibrootic tissue in those interstatial tears so you can remodel that over time and that's where BBC can be helpful u very
that's where BBC can be helpful u very helpful and and TB4 also um did that answer your question yeah which it does makes a lot of sense you know because I think about from the side of, you know, where where I hear people wanting to use it the most, right? Sure. And, you know, when you look at big picture, like, okay, yeah, it seems like it's something that can help aid in recovery, can help aid in kind of setting the stage, so to speak, for these things to take place, but it's not the magic wand that's going to put it back together. But I think, you know, by setting that stage and creating that environment in which that can occur, I mean, that's ultimately what people are looking for. And I think what ultimately people are lacking, what about in the case of people that have injuries that were more long-term that have resulted in, you know, formation of actually, you know what, I have a better better question because you kind of answered that one already. What about from a nerve regrowth perspective? Okay, let's say someone has an injury, maybe a a disc issue or something that has resulted in some some nerve damage, right? Is there any evidence in that case? And if we take it one step further with that, is there any evidence in being able to help with the development of new movement patterns if there is nerve growth potential? So that's a that's another good question and I think people are led a little astray with that. It it's not going to repair a nerve. It's it's going to help the environment of the nerve pain of the potentially some of the um uh the neurogenic
um uh the neurogenic um uh the uh neuropathy type of issues that can happen. It can definitely work on improving some of those aspects of where neuropathies can be significantly uh painful and problems with um uh with the B with BPC but even more so with thyus beta 4 with neuropathies. Um but the issue of repairing and regenerating nerves with TB4 just or with BPC 157 that doesn't happen. Yeah, I'm glad to hear you say that because there's a lot of people that say that it does and it's never made sense to me because that nerve regrowth is a very slow difficult thing. Let me just definitively say that's complete bull. Good. All right. Yeah. That just doesn't happen. So then um and that that's where and that's so interesting where you I love you bringing this stuff up because you see a somebody who claims to be an expert and is reading a piece of paper and says and there's nerve regrowth and you're like oh my god they can't be telling people this. You painted it perfectly that it it creates a more favorable environment for recovery to occur. Correct. So it creates the So then if you're doing all the right things, it's just exacerbating in a positive way or amplifying those good things that you're doing because now you've got an environment that's favorable and it's just like it's all the more impetus to say, okay, now I'm going to be adequate with my nutrition and my recovery and my work that I need to do. Yeah. And there will be so so what we haven't gotten into and it was
what we haven't gotten into and it was beyond this but so BBC can be an adgiant another something used with other things coming down the pike that are going to be that are already here. So you want to so BBC think of it about improving the environment like I said that that the extracellular matrix well all that stuff has to be per has to be right for a nerve if it is regrowing or if it is trying to be if you're trying to establish that well there are other things coming that are going to be here at some point where we're going to be able to work on regenerating nerves but you want to be able to have the environment right at the same time. It's why there's not one magic bullet to anything, of course. It's it's a combination of things. And so, and we're already doing that to some degree, but I can't it's something I can't talk about right now. Okay. Well, so in that that we can close the book on BPC for a little bit. Let's talk about the secret. Let's talk about, you know, GHRPS, which you know, personally I have had tremendous results with. I mean, I've felt like more recovery with those sons of than I have in a long long time. So like I'm personal anecdote a big fan. Uh let's maybe talk well actually there's a lot of them. So let me just ask you what are your favorite security dogs like personally you can talk about maybe for patients but personally you're an inshape guy. Uh I don't know how old you are but you look incredible for your age. So 63. Okay. Yeah. So I was going to say if you said you were 37 or something I was going to
you were 37 or something I was going to be like but 63 I'm I'm stronger than I was when I was 30 40 50. I'm smarter. I'm I mean I feel unstoppable. I'm I'm fortunate that I I've and and that's not just because of peptides, but it's it's the whole scenario, right? It's the diet, it's the exercise, which you got to be religious about, and it's the uh sleep uh and then it is the peptides, you know, for other reasons. Well, I mean, speaking of sleep, that is probably why like CJC became a really good friend of mine. I mean, the sleep that I got from that sucker. That that alone, it was worth it, right? Just being able to get the sleep. So, um, so let's Yeah, let's talk. So the I I will tell you that I have I'm a fan of all of them because I like to rotate through them. Okay. It's kind of like think of it like this. It's like exercise. Um, if you just do bench, the same bench all the time, where are you going to get? Nowhere, right? You'll get to a point, but then if you want to keep moving and if you want to keep working on getting stronger or you want to work on different parts of the pack, you got to do different exercises, you know. So, um, you know, you you have incline, you have decline, you have cable, you got all these things you can do to work on that, right? So think of that as the same way with I like to have the body adapt to different secrets. I like my body to continue to
secrets. I like my body to continue to adapt to different challenges. Um and and so when I say that I like So I like modified 129. I like CJC. I like um GHRP2. I like GHRP6. I like hexarellin. I like tesmarellin. So I've named some GHRH's. I've named some GHRPS. Um they're all they're they're all different and and so it it's like it's all about how what you want to accomplish. So, let's just say the easiest one for me to utilize with patients is Tesmarellin because it's a once a day injection. Um, and it's uh it's a GHR um that does a great job of again remember these are secrets that that re that signal the anterior pituitary to release physiologic growth hormone. enough of physiologic growth hormone and then downstream IGF one. It's not a it's not like giving somebody growth hormone where you're constantly bleeding this because they're going to pulse it out. So, it's a physiologic response that the body's ready for and knows how to handle. And I think one other point I should bring up is that I like to
should bring up is that I like to bring up with these secrets is again you're you're giving your antior pituitary the opportunity pu to produce growth hormone at a physiologic level. Um that that reacts to what the body is stimulating typically the release of growth hormone for. Meaning there are hundred different isoforms of growth hormone. So the body will release different types of growth hormone isoforms depending on if it's immune regulated, if it's muscle repair related, if it's stress related because growth hormone has so many uh it it covers it's the master regulatory um hormone. Um so when people take synthetic growth hormone, they're taking one isoform. it's a repair type of growth hormone, which makes no sense, right? If you're trying to mimic growth hormone production, but we didn't know that until, you know, it's things we've learned over time. And and the problem with taking growth hormone by itself is it just bleeds constantly, which you don't want cell receptors to have and and it causes premature scinessence of cells. So, it we already know all the bad stuff that happens with that. And unfortunately, we had to learn that. But now we've, you know, we've got these secrets that do something that's physiologic. So you've got hexarellin that I like because it's a once a day. Um it's easier to hexelin or tame. I'm sorry. Thank you.
tame. I'm sorry. Thank you. Tasmarellin is once a day. Um and that is something that you can with a GHR. you don't have to be as concerned with receptor um uh uh tolerance, okay, and resistance. So, you can get away with keeping people on those longer. Okay. Um GHRPS can cause receptor tolerance and so so forth. So, those are the ones after about a month. I've noticed after about a month of the GHPS, it was like, okay, I'm noticing I need more to get the job done. Yeah. Well, it depends. You know, everybody's individual. It depends on which one you're using um and how much of it you're using. Um, so the nice thing about the nicer things about the other GHRES and the GHRP in particular is that you can each time you use the GHRP, you're you're for sure going to get a release of growth hormone because it it inhibits somatastatin, which is typically what inhibits growth hormone release. So it's why you combine it with a GHR sometimes to make sure you get that release at that time. But is that what the DAC is usually like the CJC with DACK or No, that the DAC allows it. It expands the halflife from 20 to 30 minutes to like 4 to 6 days. Got it. Yeah. And that's I try to stay away from it. That can be useful, but I
away from it. That can be useful, but I I stay away from CJC with Dak most of the time and don't really focus on teaching providers that because that can get you into super physiologic levels. Like, oops, you're on top of another Y. Yep. Yeah. You you got to have to consider a growth hormone. You got about three hours of that pulse. Okay. and before you would consider doing another one to take advantage of. Um, like there are ways to work with these peptides that you can truly do some I think incredible things. But, uh, going back to that pulsing, if you're using a GHRP, you can use it in the morning. Um, get your three-hour pulse. You can use it before or after a workout. Um, and use it at night again. And so, you're getting three guaranteed pulses. And you know how many times do people pulse out growth hormone? Different with individuals. It can be some could be twice a day, some can be six to eight times a day. Everybody's a little different, but you can set up the pulsing however you want. Um, does that make sense? So you can really do some if you're you can really tailor these things to the individual or or give them the opportunity to toggle with these things and um you pretty pretty massive pulse when you go in a sauna. You could almost time it before before sauna usage. Kind of interesting to align with that. Yeah. So there's there Yeah, it well it's
there Yeah, it well it's um you're again it it's um it's all of what you're trying to achieve with these. Um and so did that answer your question as far as which ones or should I the uh where do you want me to go? personal question with the tessamellin when I um I found that my that I actually I don't know maybe it's just me but the tessamellin I was almost having so much energy from it I don't know that it was actually affecting my sleep negatively to the point where like I had to start taking it in the morning and even then I had a little bit of a negative effect when it came to sleep so I went back to the pearalin CJC um the only kind of answer that I can come up with is because I'm metabolically healthy is like ultimately producing too much energy. It was just like I was just stimulated. I was ready to go all the time. Sure. Well, you probably were just you're sensitive to that and you're it was doing a a better job. Like you you could have just reduced the dosing. Yeah. So it you run into that for sure. I mean you get you this is where it this is where you have to tailor things with people. I mean you have to work you help them in in finding their thresholds that are possible. and uh and tesmarellin. So tesmarellin can raise it's kind of like hexarellin. Tesmearel and hexarellin are the more powerful GHRH's and GHRPS and they'll raise they'll elevate more growth hormone and elevate more IGF-1 production. So that's that's you're what
production. So that's that's you're what you're saying matches up and you probably just had too much. Yeah. But well I didn't throw it away. So, um, what about the the potential side effect of a glucose spike with them? Uh, is that something that people need to be aware of? Is it really not that noticeable? Well, so yeah, that's not um you are so what what you're trying to do is you're trying to set up the um you're actually what you're really doing with these peptides is you're setting up the metabolic aspects of the cell to be at its ultimate to handle that process of of bringing in the glucose. So, it's it's rising. It's it's potentially in some people, doesn't happen in everybody, but it's it's raising sometime sometimes that glucose to be more utilized. Uh it it just depends. Got it. Um but it's it's um uh so there's so many things uh your so when you're using these secrets they're their focus is on improving the efficiencies again of the cell by improving beta oxidation of fat. That's one of the big things is is improving that efficiency of the mitochondria to utilize fat and glucose, you know, be more flexible, but to utilize fat better because by improving
utilize fat better because by improving those efficiencies, uh, you're going to utilize glucose better. Um, you're going to improve glycolysis when you're making the cell more efficient. And that's what it's doing. It's it's doing it from that aspect of of increasing um the production of uh PGC1 alpha that influences the then the TFAM we talked about. So you're it's going to increase the transcription factors that are necessary to make more mitochondria. So you're making more mitochondria for the cell to bring in more oxygen to utilize more of that glucose, right? So and the fatty acids that it's going to use to be depending on what the demand is um to meet those needs. So you're you're working on mitochondrial biogenesis. You're also working on um improving the the storage of fat as glycogen and lipids. You're you're working on the improvement of lipids through uh PPR gamma and some other aspects of of storing fat. Um and you're you're improving the the pool of NAD for the cell. And this is what I think is just wonderful is that you're setting up
is that you're setting up the system for the cell to have a bigger pool of NAD available to utilize it where it needs to. Meaning the nucleus, the mitochondria, the cytoplasm. This is where it gets into this all this this stuff about you know giving NAD exogenously or giving using these precursors is in my opinion insane because the cell is knows where it needs it and how to utilize it. If you're providing something you're going to create you're creating a negative feedback telling that cell oh you don't need to make this anymore. Oh, you don't need to do you're never going to get anywhere. You're going to become dependent on something like that. It's going to make you worse. And it does. Um, now there are places where sometimes short period of time that could be helpful. Uh, but in in the scheme of it, this NAD NADH ratio is a really important thing to pay attention to. And that's where these secrets are just they're they're tremendous in how they allow the cell to what we talked about with the GLP1s and how they improve the flexibility and the efficiency of the cell and that carries on to the um to the cell. So that improves the autophagy of the cell. It improves
the autophagy of the cell. It improves AMPK. It allows the cell to be better at autophagy, mphagy, which I'm going to talk about in one second. And then it sets the the cell up with with IGF-1. So IGF-1' s the downstream metabolite of growth hormone. Well, that IGF-1 comes into play now to upregulate what? That other pathway we talked about the A the PI3K AKT mTor pathway. So there phases of how this works and how it's it's just it it creates that metabolic efficiency of everything you want to happen with exercise and then recovery and repair. And what hap and unfortunately you know as we age um we don't lose the machinery to produce growth hormone but we lose because of life and stressors um environmental sleep food stress all these things that happen they restrict growth hormone production. And so by the time you're, you know, when you're in your 50s, you're you're producing maybe half of the growth hormone you potentially can produce. So you don't need much to make a difference. That's why this is so fantastic is that you're again utilizing physiologic doses, right, to to make this stuff happen. Well, this gets into, you know, the
Well, this gets into, you know, the muscle building problems. you know, why why when you get older uh do you have issues with with um maybe maintaining strength or truly building muscle? Well, it's because you're losing mitochondrial efficiencies. You're losing these aspects that are so vital to the cell to be able to utilize that glucose, those fatty acids, and those proteins. So if if more importantly you know if if do you want to go down this or okay so this is so cool. So there's this aspect of the mitochondria where it goes through fision and fusion. Um there is a uh there's a trans there there's a trans there's a uh a factor a regulatory factor called mofusion 2 that is very important in calcium regulation in the cell in combining the mitochondria to the endopplasmic reticulum to keep them close together to to have this process of calcium um metabolism working well in the Wow. Well, monofusion 2 is very important in um muscle building. It it's essential and it's essential in the
essential and it's essential in the process of something you brought up before when you said something called satellite cells and stem cells. And we'll we'll jump into that in just a second. Um but that mofusion 2 is a very important factor that that is important in the ensuring the process of uh maturation of muscle cells but also differentiation and and then there's something else we talked about hypoxic inducing factor 1 alpha that's something that hangs around too much and and doesn't allow muscle it it turns off things that are important for muscle to to rebuild. So if you buy into that and I I'm not going to go through the the pathways with it, but the secrets help in help control that hypoxic inducing factor to make it where to to make it modulate like it's supposed to. and and that that's really what I just talked about the mofusion 2 and hypoxicinducing factor 1 alpha are some they play key roles in truly allowing people to build muscle and to uh it's why they can't take advantage of working out and and building muscle because they don't have control of that. So when you hear all this stuff about hey I'm going to change your life by hey you're going to take this different type of protein or you're going to take this
protein or you're going to take this because it's got chromium in it and it's got amalopactin in it and we're going to change the world of muscle building. That's bull. It's going to be something that helps muscle protein synthesis. That's okay. It's going to help it to some degree. But you got to get to the root causes of allowing that muscle protein synthesis to be relevant. And to be relevant, so let's jump into now where okay, when I go and work out, what am I doing? I'm breaking down muscle. So muscle is going to break down, correct? It's you're you're tearing up tissue. You're tearing up actin and meosin fibbrals. And what happens? That mechanical force releases the satellite cells that you brought up. Those satellite cells are crucial to repair and recovery of that muscle and rebuilding of that muscle. And those satellite cells are stem cells. Those satellite cells, they're required to be in a quiescent state. What does quiescent mean? It means they're just dormant, but they have to be ready to react. And if they're not dormant and to be maintained dormant, they have to be in a metabolically flexible state. So here we come back to redux. come back to
here we come back to redux. come back to all these things that are so important about now we got this satellite cell that if we have some metabolic inefficiencies that satellite cell isn't going to do its job either. So these GLP or these GLP1s these uh secrets we're talking about they can help maintain that satellite cell in a quiescent state to be ready to go and to self-renew. So that stress happens to the muscle that satellite cell comes out to say okay let's start repairing and let's let's that satellite cell can turn into a u a muscle cell and but to do it it needs help and so it has something called IGF 1EC which is mechanical growth factor it it it's created by the stress. So if you know that so so that starts the maturation and the proliferation of these cells and then there's this last stage of where it has to differentiate into a muscle cell and that is where IGF1 itself which is from growth hormone and made by the liver that's where that comes in to to complete the differentiation phase. Got it? So what I'm all I'm trying to do is give you this. So, you've got a secret
give you this. So, you've got a secret that's helping you and helping these iso forms be more prevalent, be there, um making them. you're physiologically you're creating those um and so gosh I could get into more about all of those but I think I I don't want to confuse people but the so what I'm telling you with a secret you're doing so much to to enable now that muscle cell to repair to develop um to maturate proliferate differentiate into a new fused with maybe another muscle cell um and you're rebuilding. Yeah. I always try to describe I mean it's it's a probably inaccurate analogy but it paints the picture enough you know it's like satellite sol it sounds just like the name implies right it's like think of it as like hovering over you know in its quiescent state and then um it's you you're essentially connecting to the satellite and you're growing right I mean that's a very oversimplification of it but it gives people the idea right so if you're creating that environment where that quescent state can actually it can be more receptive and have the ability to I say fuse is probably the inaccurate word but essentially allowing that muscle to kind of go okay now we're going up to the satellite right you're going up to the satellite um which is all extremely important all while also probably encouraging some fat loss in the process because you have energy now being allocated over there which is a highly I
allocated over there which is a highly I mean it's a metabolically somewhat expensive process to build muscle so you think about that's kind of a good thing for the sake of a body recomposition. Oh, absolutely. Because you're the more you make, the more mitochondria there are, the more demand there is for energy. So, you've got muscle that's working 24 / 7 for you that demands energy. So, you're you're increasing your metabolism. So, you've got something that, you know, when people talk about fat loss, they ought to think about, hey, wow, what if I had this reservoir that was just demanding energy 247? Well, that's what you're doing with these GHRPS and GHRES. I know there is I don't really consider it a big problem, but you know, you have an increase in ghrelin, right? Or it's like it's stimulating the ghrein um like kind of a ghrelin agonist or something, right? So, it's kind of has the potential to make you a little hungry or how what's this interplay with ghrein? I know there's something going on there. That depends on So, grein is a GHRP. Really? I didn't know that. Yeah. Interesting. Grein is a it's makes sense from a survival mechanism. When you get hungry, you're going to pulse so that you preserve. Correct. Got it. It it it's where a lot of the research started with looking at ghrelin. And so, so like so that's where we can do some really interesting things. So, uh like GHRP6 will make people very hungry because it really mimics ghrein. sign. It's it's very close to mimicking
It's it's very close to mimicking ghrelin. Nah, that makes that's that's pretty neutral. Um, hexarellin can make people hungry. So it's the GHRP that it's it's creating that hunger. Interesting. Okay. So, if someone is, you know, pumping out more IGF and they're eating like the wrong kinds of foods, they're eating like a dirty bastard. Is that are you putting yourself in a because you know IGF could potentially increase fat accumulation too if you're eating like total garbage, right? So I mean is it kind of at that point in time it's not a license to eat like crap. It's really taking this time to because I think that's where No, you're absolutely perhaps people could run into trouble if they're not careful, right? Oh, here I'm taking this stuff. Let me go ahead and eat whatever the hell I want. No, you're absolutely right. I mean, that's where if you can really start this goes so much farther. If you understand what your macronutrients are, you you can make a significant difference in how those work for you. But absolutely, if you're um it can work against you, too. Yeah. I'm glad to hear you say that because you know, you have people that will will pump peptides and they'll say, "No, it's not." He's like, "No, that's the reality is that IGF is going to grow whatever." And it's like, if you're going to eat like crap, it's going to grow crap, you know, period. You know, this is and it's maybe not to the extreme, but it's definitely making a more favorable environment for that, too. Yeah. But if you think about what we started with here with our
what we started with here with our discussions, it's you're if you're not paying attention to that holy grail of metabolism and understanding if you're going to feed it, you're going to create that imbalance of redux and that redux imbalance. No matter what that IGF-1 is there for, you you're working against it for sure. What about quickly before we kind of wrap this one up on the muscle building side, what about the direct utilization of IGF, right? There's IGF peptides that people can take just uh there's even some of these other forms, right? People can actually take MGF. People can utilize IGFDEES and LR31. Are these really more advanced players? Like if someone is really just looking at this, we probably should just be looking at the GHRPS and GHRH's, but yes. So the the IGS more utilized in the bodybuilding spectrum or or what's the take there? Well, it is more advanced and it's all about timing and I think it's uh I mean my you the purpose my purpose was always for injury um and helping people accelerate through injury or um uh or if there were specific um you know if you've had an injured hamstring or quad or calf or and you're trying to work on one muscle group. That's the other thing you got to when you're using those you're specifically working on a muscle group because it's direct um you're being more directed like with
you're being more directed like with mechanical growth factor and IGF-1 LR if for injury or for muscle growth like if you're going to work on building someone's biceps or someone's quads or someone's pecs or you have to be utilizing those injections specifically into those muscle groups. Oops. Not systemically. Um, you you could try you can do it systemically, but you're not going to have the success if you go right into the muscle. Not so cute, but you got to go into the muscle. And that's be that's about timing. So mechanical growth factor, you're going to use that right when you're exercising because you're breaking down. And then the the other types of IGF-1 LR for instance you're going to use either 12 hours or the next day when you're going through the differentiation phase of muscle. So you your timing has to be right in using those. Is dees totally worthless because it's a I mean it's a small fragment, isn't it? Like it's like Yeah. I like the LR. You need to hang it around a little bit. Yeah. I I won't say it's useless. Um uh but it's not you're you want to hang it around. Yeah, it seems as I mean anecdotally I have used IGFTEES and I found that it I feel like it worked really well for like small muscle groups. Um you know, but other than that, I don't think I really felt much out of it. And it's hard to say if I really got much out of it, but I did
really got much out of it, but I did feel like um I got maybe got a little bicep growth out of it or something like that when I used it. But uh yeah, it seems like it's definitely it's a you got to be right on par with your timing, and it just seems like Yeah, it was kind of a at the mercy of timing all the time. Mhm. Well, uh Okay. So, as far as the muscle building, we've got the BPC 157, we've got the secrets, and you say like you'd start most people with uh tissela. That's kind of a good starting place. Well, I gosh, what what can I say? It's something it's an easier it's easier for people that that aren't accustomed to using subcutaneous injections. So, it's just an easy way to get people started. If people aren't adverse to that, I pro I usually do go right to like the CJCL or and I um I like to uh Yeah. I mean, I I won't get into So, CJCL's a good start, you know. Yeah. And one other one I didn't mention was the oral MK0677. Um, that's an oral GHRP mimedic. It's not a true peptide, but it's very clo it acts very close like a peptide, and it's been classified in that area. So, and that's a that's another um uh peptide that's that's utilized in muscle building. it it creates a little more uh it's uh more IGF-1 is produced
more uh it's uh more IGF-1 is produced with that one and I tend to see it having more it it tends to pull more water into muscle too. Um and females don't like that. Yeah. Um so I found that that's one area where I don't use an oral like that um for females but some can tolerate it but it's just something to bring up. I mean, I saw a nice amount of intracellular water with uh CJC. I mean, not not a tremendous amount, but enough to where the muscles felt full. Um, for me, it made dieting a lot easier. Like, in terms of I'm always kind of dieting, doing something stupid, you know, but it's just like for me it made it okay. Well, yeah, the muscle bellies are full in a depleted state, which made it feel from a mechanical perspective, I like maintain strength really well, even though I was severely depleted. Um, so yeah, I understand the women are yeah, it's like water is water at that rate and it's but the, you know, guys, we like the intercellular water a little bit as long as it's not kind of that subcq puffiness. So, uh, Doc, I'll link out to all your social channels down below, but then you just launched a uh, pretty badass course, too. So, where can everyone find that? Uh, they can find that at the srpinstitute. org. Uh, that is, uh, again, our education services for our healthcare providers, but actually for everyone. Um and I I want to make a point there if I can in a second if I could closing this. Um that's our exercise performance um uh course that
exercise performance um uh course that is uh about 16 hours of video um that really it takes a dive into where I think uh everybody should be learning about the and understanding exercise and diet and sleep and circadian clock. I mean I put it all together. microbiome. It It's I think it's a killer course. Um and it's it's only going to keep getting better. So, if people have time to look at that, awesome. Um, and I guess I I was going to say something, but I was going to say, well, what I was going to say is that it's interesting that in our group of um in our we started off uh as a medical providing institution for education and uh we have a tremendous support from uh physicians uh healthcare providers, NPs, PAS uh and chiropractors. And what's really been amazing is this surge in strength trainers and um physical therapists and um uh and trainers in uh in this area and they are smart. these people are on it and it's
these people are on it and it's intimidating in these meetings sometimes where uh where you have healthc care providers that are trying to that are anxious to learn because their patients are demanding it and then you've got a person who's working with people every day in this area of you know as a um as a trainer or a strength coach or or any aspect of that and they know And and it's just so awesome to kind of just see that dichotomy, but to see collaboration. I mean, this is what I think we do so well is we're building a group of people that, you know, geting ego out the door. Everybody's there to learn and to add and and once you let that happen, it's amazing. And and I get to be part of that and it's so fun to see that. And so I just want to bring that up that it's uh there are a lot of people with a lot of knowledge out there and and it's not the physician sometimes that has all that knowledge and and I don't mean that in a bad way. It it it's it's just they didn't get that type of training. Newtonian physics versus boots on the ground. Yeah. And it's it's so valuable to hear that discussion. Yeah. Um, I can't say enough about it. And that's we've been blessed to have that explosion and uh it's only going to get bigger. So,
get it's only going to get bigger. So, amen to that, brother. Yeah. Thanks, man. Yeah, you got it.
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"A compound can be interesting without being ready to become a personal protocol." — Contrast Collective
Peptides sit at an uncomfortable intersection: biologically fascinating, commercially amplified, and often ahead of high-quality human evidence. This conversation explores mechanisms linked to muscle repair and signaling, but mechanisms are not the same as outcomes. For a longevity practice, that distinction matters. The body is not persuaded by hype. It responds to training, recovery, nutrition, sleep, and carefully supervised medicine when medicine is appropriate.
The most reliable signal for building muscle remains progressive mechanical tension supported by enough energy, protein, and recovery. Compounds discussed in peptide culture are often framed as shortcuts, yet the deeper lesson is about repair biology: inflammation, remodeling, and adaptation all have timing. A resilient body needs the stress and the pause.
This is a subject for qualified clinicians, regulated products, and careful risk assessment. Online peptide enthusiasm can blur animal data, early mechanistic work, and human treatment claims. A grounded approach keeps those categories separate.
Treat peptide claims as medical claims, not wellness tips.
Build the foundation first: strength training, protein, sleep, and recovery.
If regenerative medicine is relevant, discuss it with a qualified clinician who can explain evidence, risks, and legality.
The strongest message is restraint: use science to sharpen the practice, not to decorate a trend. The body adapts best when the signal is clear, repeated, and supported by recovery.
