The GLP-1 conversation has moved faster than our collective understanding. Beneath the noise is a more useful question: how do these medicines fit into metabolic repair, muscle, inflammation, and long-term resilience?
[Music] Hi, and welcome to the Restorative Wellness Clinicians Corner, a video series exclusively for functional health professionals, where we interview the top experts in the latest research, products, tools, and best practices for getting your clients exceptional results. Hello everybody. Welcome to today's episode of the RWS Clinicians Corner. We are in for such a treat today. This is by far the single most requested topic um that I think we've ever had in the history of the clinicians corner. And I am so excited to introduce our interviewee, our guest, Dr. Tina Moore. She has been for nearly 30 years in the medical field. She's a leading expert in holistic regenerative medicine and metabolic health. She's duallicicensed as a naturopathic physician and chiropractor. She blends traditional and alternative approaches to help people heal at the root and build long-term resilience. She is known for her bold exploration of therapies like saglutide. We are going to be talking a lot about this today um as longevity tools using them in ways that most are not um at least not in the mainstream yet and not properly. We'll dig into lots of nuance there. Dr. Tina is a passionate advocate for medical autonomy and personal responsibility in health. She hosts the Dr. Tina Show, a topranked podcast in health and wellness, and she speaks internationally on strength, metabolic
internationally on strength, metabolic healing, and personal empowerment. She also coaches fellow clinicians on building thriving online practices beyond the constraints of insurance. She lives in Oregon, it sounds like now, maybe also Arizona soon, with her husband, daughter, and their beloved dog. Dr. Tina, welcome. Thank you. Thanks for having me. I'm excited to be here. I am so excited to have you here. There we go. Okay, let's start just at the beginning. Um, what got you you we're going to talk about definitions and all the things, but you work with these GLP ones in a way that nobody else does. What did what inspired you on this path? What got you experimenting in this way? Yeah, so my background is in regenerative medicine. I was fortunate enough to work for an amazing physician starting out as his receptionist right when I got out of undergrad and he was doing u this is decades ago. He was doing therapies like prolotherapy which eventually morphed into plateletri plasma which eventually morphed into uh stem cells but my background is predominantly muscularkeeletal medicine and surprisingly there was a lot of hormone replacement therapy that went on there because a lot of pain is due to hormonal fluxes and so I learned very early on how to treat hormonal imbalances even in you know menrating women and in young men people who were just needing a little bit of something to get them over that hump. And whatever that little spit of something was was for me to figure out. I I run labs because labs cover your ass as a
because labs cover your ass as a clinician, but I'm much more interested in symptomology and symptom resolution. And so whenever anyone says, "Hey, can you look at my labs? I'm permenopausal." And I'm like, "Honey, you need hormones. It's just a matter of like what dose and what symptoms are we trying to go for?" So there's always short-term and long-term goals. Anyway, fast forward, peptides came on the scene. I was winding down my big clinical practice. My mentor unfortunately passed away from cancer in 2013. I took over his big practice. Things were winding down right before COVID hit. I'm in Oregon and I'm like, "Bye, I'm out." Because I was not doing I'm not I wasn't playing the game. Um, and so years go by and my podcast producer is just all over me about talking about Ozic for weight loss. And my whole platform is about strength training and metabolic health. And so I'm all about getting stronger, not skinny. I could care less about your atapost tissue levels unless they're extreme and they're causing you inflammation and and terrible, you know, outcomes, poor health outcomes. I'm much more interested in one's metabolic health overall. That's how your joints are ultimately going to feel good. That's how your hormones are going to be happy. And so, I started digging into the literature because I wasn't going to go talking out my butt about something I don't talk about. I don't talk about weight loss. And that was the summer, that was a couple summers ago. So that was when like all the sensationalized clickbait headlines were all over the internet and it was something very weird was happening. I pushed back against the narrative in 2020 and I pushed back pretty hard against mandates and lockdowns and the one thing my message was always the same which was become
was always the same which was become more resilient. Not to say that people weren't going to fall ill from this virus or that it wasn't real or gnarly but like we there were many things we could do to bolster our health overall. And I think that can resonate with any audience if I just hadn't been censored so heavily, which was, you know, lift weights, get enough protein, eat nutrient-dense food, take good care of yourself, so your immune system is your friend, not your foe. And I went into looking at GLP1's kind of the same way, like, well, definitely having extreme obesity is not favorable to outcomes for immune system or any other health system. There's got to be something to these peptides. And I also recognized that these have been used for type two diabetes for decades. It wasn't until the message about weight loss came out that people started losing their minds. And what was happening that cued my interest because in 2020 a lot of propaganda came at me and I had a pretty sizable platform that grew very fast. So I was privy to quite literally in the line of fire of the censorship industrial complex. When I found the literature that I found on GLP1s, which had nothing to do with weight loss and type two diabetes, but instead this whole tipto toe plethora of benefits from the brain through every organ system for healing, regeneration, and anti-inflammatory mechanisms. I started talking about this on my podcast. The same propaganda machine came at me, the same bots, the same push back, the same everything. And what I was saying about the media was my functional medicine community was singing the same song as the mainstream media. And I was like,
the mainstream media. And I was like, that sounds like propaganda. What's going on? Like why are all my functional medicine baddies over here saying the same clickbay kind of nonsense that it was so sensationalized about OMIC that we were seeing all over the media. So of course, the more they pushed on me, the more tenacious I got because I'm just that way. So, I was digging in harder into the research and what I found was not at all what we were being told. It's still not what we're being told. There's so there's such a plethora of potential benefits here, not in just in mice and rat studies, but in human studies. And we have piles and piles of data. And after I came out talking about it, I took so much heat and it was very reminiscent of 2020. So that's an interesting point we should come back to is why do they not want this message getting out? And then I was deplatformed last year at 232, 000 last fall, the same week that Eli Liy released the Zetbound vials. So that's interesting. Um I don't know, but these peptides have incredible potential and I knew when I started researching them and figuring this out that my mentor would have probably loved them. They're an incredible tool. And one of the many things that was difficult in clinical practice that is still to this day still frustrating is when we end up with someone who's doing everything right, probably better than I am, and they're just stuck. They're stuck somewhere. And it's not always weight. Sometimes it's weight related, but it's often inflammation related. And it's often systems gone arry. These peptides come
systems gone arry. These peptides come in and do a really spectacular job of cleaning that up. So after I played with them for a while with my patient base and with anyone who would play with them. I called every clinician friend I had. I called every colleague I had and said you would be a great candidate. All of them had different conditions. None of them had obesity to deal with. And we started just experimenting and seeing what really ultra low doses just like I was talking about with hormones. What would that do? Because sometimes people just need a little bit of something something because we make these peptides naturally endogenously. And I thought, I wonder if some people are having a functional deficiency just like they have a functional deficiency of thyroid or functional deficiency of other hormones because they burn their system out. And the results were just amazing. So, here we are now a few years later. The inmates are running the asylum. The micro doing conversation that I started has been twisted into some kind of vanity weight loss thing, which is not at all what my message ever was, and it's still not. I don't think it's a great weight loss strategy to be honest with you. Um, and we can get into that, but it's yeah, it's just it's it's taken on a life of its own. So, I'm really glad that you're having me here to hopefully clear some things up. Yeah, 100%. What I want to do just to make sure I mean, we've all heard and there's also a lot of misinformation and confusing information about it. So, we can just start at the beginning and explain what, you know, what is GLP-1 and and what is a GLP1 agonist? So, G specifically that agonist piece. So GLP-1s are naturally occurring signaling peptide hormones that we make in our gut in the L cells in our gut and
in our gut in the L cells in our gut and we also make that in our brain in a few different segments of our brain. We have receptors throughout our entire body. This is what I was finding years ago in the literature and I was like wait a minute if it's made in the brain and it's used in the brain it's probably pretty important in the brain. There are other signaling peptide hormones that people might be familiar with. Insulin, leptin, ghrein, there's a bunch of them. They work together as an orchestra. They work together in harmony. And what I found at least in rat data in relationship to the vagus nerve and its impact throughout these systems, these pep these signaling peptide hormones don't work in isolation and they don't work without each other. And so we probably have all heard about leptin uh resistance. We've heard of insulin resistance. I do believe there's probably GLP-1 resistance. Um, and it I think most notably people know them for reducing appetite, slowing down gastrointestinal motility, making you feel fuller longer. But that is just the tip of the iceberg. They do a whole lot of other things throughout the body. And so we make it, it's in our system for a very short amount of time, a few hours after it's stimulated. It's stimulated by the presence of glucose in our guts. It's stimulated by a bolus of food. So me a mech, you know, like a mechanical bolus will stimulate the L cells if they're working. I have a theory that not every ones are working well and protein. There's all bidters. There's all kinds of things that will stimulate GLP-1 in the gut. Um I don't know about the brain what stimulates it there, but anyway, GLP1 agonists are simply peptides. So we maybe have heard of
peptides. So we maybe have heard of BPC-157. There's that gets a lot of play these days, TB500. There's a lot of peptides available over the counter and in injectable form. So pill and injectable form for regeneration, for inflammation, all kinds of things. This is just another peptide. Peptides are strings of amino acids in its most simplistic form. And when you take strings of peptides, like the kindergarten version is strings of peptides make proteins. That's what we're all made of, right? So these are naturally occurring peptides. And big pharma has simply tweaked one portion of that peptide to make it last longer. So the halflife is like five to maybe four, five to seven days in the body versus a few hours. So that's it in a nutshell. That's semiglutide or semaclutide. And then there's another version that's very popular called tzepatide which is a dual agonist. And when I when you ask about agonism that means it sits on the receptor and it makes it go. That's it. It just sits on your GLP1 receptor in your body and it makes the cellular processes that that peptide binding should make the cell do. It makes it do. Um, antagonism is where it would do the opposite. It would stop whatever process is supposed to happen cellularly. So, Tzepatite is a dual aagonist. It stimulates GLP-1 and it stimulates GIP. So, it has two mechanisms that it does. Little bit different beast actually, but similar outcomes in the world of weight loss and type 2 diabetes metabolic health. Okay? And there's so many different ones. I won't have you go through all of them, but when you start looking this up, you know, you've got luraglutide, dulaglutide, eenitide, like there's so
dulaglutide, eenitide, like there's so many of these. Are these just really different in terms of how long they're acting, the dosing, whether it's injectable, the duration, that kind of thing. Is it just like all different flavors of the same of these two basically? Just different generations. They're just getting nicer. They're getting nicer, more tolerable. Compliance is going up. You know, way back with Xenotide, you had to inject yourself multiple times a day with Lyric. You know, it so compliance goes down or goes up, I'm sorry, when we only have to do one shot a week versus and they're now looking at month-long agonists that Yeah. So interesting there. But some oral versions, the compounding world, I think, has sublingual and there's all kinds of iterations. I have only worked with the injectable form because I, like I said, my background was in regenerative uh injection therapy. So, anything that comes out of a needle I'm a fan of because I can control dosage way better and I can control outcomes much better and expectations. When we get into oral or sublingual, who knows what's going to do what, right. That makes a lot of sense. So, let's talk about, you know, the fact that you, you know, that was a everyone's freaking out about this for weight loss obviously. Um, and that's a bold claim that it's not the best weight loss strategy and and you're using it for so many other things. So, I'd really love to unpack the clinical utility of this at a much smaller, more manageable dose and not thinking about it as just weight loss. Well, I I think I should have called it personalized dosing and not so much micro doing. I think, you know, but I truly when I say micro dosing, I mean a fifth to a tenth of the standard starting dose. I'm talking minuscule
starting dose. I'm talking minuscule amounts. This strategy was originally for me I was thinking wow I found all of these studies showing the neurogenerative benefits the quelling of neuroinflammation the calming of micro gleal cells that was really interesting to me in the brain right because I'm a pain doctor I'm a brain and pain doctor I'm a chiropractor too so everything central nervous system an inflamed brain will do all kind wreak havoc downstream everywhere immune system dysregulation pain centralized pain syndromes you name it and so when I started researching these I went top down. I was like, "What's it doing in the brain? What's it doing with pain? What's it doing in the muscularkeeletal system, you know, and on, cardiovascular system, and kind of from there, ovaries, pancreas, liver, all of it, you know, and it's doing amazing things everywhere. It works in in every organ system. It works in a regenerative, a healing, and an anti-inflammatory capacity. The reason I say micro doing is not the ba best weight loss strategy. My patient base is predominantly healthy, lean, fit individuals. And that's not an elitist stance. It is a when you are doing regenerative injection therapies, they don't work on inflamed people who have a lot of inflammatory fat on their bodies because you're taking their own body fluids and cells and using them to heal them. So, we need it. And as I would tell patients, and I say this with love, but if I took your in, you know, I could just look at someone and tell they were a hot mess of inflammation. If I take your hot mess of inflammation blood and I concentrate it down and I shoot it
I concentrate it down and I shoot it into your hot mess of inflammation joint or your atapost tissue that's highly inflamed and I shoot it into your inflamed joint, we're going to have a bomb go off and it's not going to go well. That's not regeneration. That's just putting a hot fire into an enclosed space, right? And so for me, I have to pre-screen everyone before I stick a needle in them because not everybody is a regenerative medicine candidate. And so in my community, it's people who are already doing all the things. They're already metabolically optimized. They're already going to the gym several times a week. They already understand the value and the necessity of muscle mass. They already eat nutrient-dense foods and their diet is a is, you know, intentional. they generally are already dabbling in some hormone replacement therapy or they're substituting the hormones that they need. And so these are pretty healthconscious people to begin with. Those people need a little tiny sprinkling of GLP1 and really miraculous things happen. If you take the average American that these are FDA approved for, that is a much more pathologic community of people. I'm not dissing them. We're just talking an entirely different kind of patient base. And so not just your average American but th you know 94% of US adults are cardioabolically compromised and that was 2018 data. So you know it's anyone's guess how that shifted in the past however many years especially considering many places went through extreme lockdowns. And so that said um that those folks are looking at a much more standardized dose. And so if you've got someone like myself or yourself and
got someone like myself or yourself and we're aging we have issues too. We could be the thinnest, leanest, fittest person on the planet doing all the things. And I've got a whole bucket full of autoimmune conditions that I have inherited or acquired, right? And probably a lot of it I did to myself through my younger years of living poorly. Um, we come with a lot of trauma. We come with adverse childhood events. How a patient comes to me is not my business, but it is my problem because I'm not here to judge. If if a woman walks into my clinic, and this was every almost every woman that would come into my clinic, all of a sudden one day would appear and she's got 15 pounds around her midsection and she's like, "I don't know what happened. Nothing has changed. I haven't changed anything. I'm still doing all the things almost like I said, probably better than I am." And with more discipline and she suddenly got this kind of layer on her body that happens in pmenopause and menopause. I call it the thickening. If you've heard that term, that's my term. It is the thickening. And you know what I'm talking about. It's It's kind of exactly what you're talking about. Yes. And that is insulin resistance happening in real time. Period. That is inflammation. And that woman's labs. I have I just saw a big menopause doctor come out on one of her reels. And she said, you know, I've been doing predominantly menopause care for the past two years and here's something I've seen. And I'm listening to her explain this. I'm like, honey, I've been seeing this for 20ome years. It's the same thing. Their cholesterol and their lipids go up. their triglycerides go up. Their lip or lipid profile starts to shift to a more pathologic one. Their
to shift to a more pathologic one. Their blood glucose glucose starts skyrocketing. Insulin starts coming up and they're not doing anything different. They're not drinking more wine. They're not eating more carbs. In fact, they're probably trying harder and doing less of those things. They become more restrictive and systems are going sideways. That's insulin resistance. And my theory, and I took a lot of heat for this, I didn't realize this was a abnormal way to treat. I say we treat that now. Like that's a right now issue. Why are we waiting 10 years until they develop full-blown diabetes? This is where I came up with the concept of micro doing a GLP-1 if there was weight loss needed. But these, this is really reserved for those who are already metabolically healthy. They just have a little fluff and it's this sort of inflammatory insulin resistant puff thickening. That's a whole different beast than somebody who has 40 pounds to lose plus that 100%. That person's really looking at a different kind of overhaul, a much more intensive intervention and very likely a higher, more standardized dose. And so something that's happened and I I just saw a Facebook ad going around with my name on it. Some guy's like, "If you like the work of Dr. Tina Moore, this guy has bought my course and started an online tele medicine clinic micro doing GLP ones for weight loss."like I've seen hundreds of and all of these companies are using my name and my podcast to sell their nonsense. This is not a sustainable weight loss strategy. Every single person I know who even did use a micro dose to get the fluff off to keep the fluff off usually
fluff off to keep the fluff off usually has to stay on it or increase their dose. That is a different strategy than what I'm talking about over here which is like other peptides BPC157 I'll use as example. I don't keep people on that all the time. We use it in a cycle and we use the lowest dose necessary. That's exactly what I'm proposing with this peptide. So when you hear micro doing GLP1s, that's what I'm talking about. I'm talking about using tiny little doses. Whatever that dose is is totally individual for the person in front of me. It's you would probably need a different dose than I would. It's based on short-term and long-term goals. It's based on what their pathologies are and what we're trying to accomplish. What are we trying to turn the dial down on? I'm not treating these overt intense pathologies like type two diabetes is a hot mess. I mean that is a a problem. Like that is a much bigger problem than a woman who's got some cellular insulin resistance and even her labs aren't showing it but her body composition is. So that's where I came up with this idea and kind of a preventative longevity strategy which seems really foreign to a lot of people. I'm sure your audience understands. I'm trying to keep the cardiovascular event from happening. I'm trying to keep the brain inflammation down so that we're not talking full-on migraines here. I'm just talking somebody who's got some brain fog as she's hitting, you know, her late 40s, early 50s. How can we help these folks? Um, you know, the the person doing all the things, but her serotic arthritis is or any of these HLAB 27 positive, you know, interopathic arthritises that are happening in so many people and they don't realize it and they've just got
don't realize it and they've just got kind of this bodywide achy joint thing that happens in middle age. Those are the people I'm talking proposing the micro dose for and we find the dose that they need that gets the job done and we cycle them on and off versus those who need weight loss and are looking at a more standardized dose forever or for very long term. Right? It's a different two different sets of patients. This is such an interesting and important piece of it and that was one of the big questions that I got from multiple people is how long are we talking here? because that is one of the the stereotypes of this is like you're on it and now you're on it for life and you're stuck in the second you get off. And I really love the clarification of this strategy that it is really kind of the icing on the cake, right? Like you're doing all of the other pieces. It's just that last little bit of dust, right? That's just going to help push things over. You are cycling on and off. Now, is this cycling is that something that is going to be a long-term strategy or is it temporary? like we do the strategy for maybe a few months or a year or two while we get things under balance as for example somebody's going through pmenopause now they're firmly on the other side there things have have kind of leveled out is is that individual able to be off of it or are they kind of continually needing to bring it back in well in my world we don't ever go off anything I'm not going off my thyroid and I'm not going off my estrogen and I'm not going off my progesterone or my testosterone ever you know and I'm never going to not need BPC57 every once in a while because I'm gonna keep hurting myself and I'm going to keep having leaky gut issues when who knows what I who knows what goes down my mouth in Mexico and I end
goes down my mouth in Mexico and I end up with something, right? And so the way that I look at it is like these are just tools in a comprehensive toolbox and I'm going to use them as I need them. So, I went off of GLP1s for a very extended amount of time and then all of a sudden, you know, the pain, my chronic pain that I have just really was not managing itself too well. Whe whether that's stress, like what's coming at me that I can't control variables that are out of my control. I can control what I can control and I I can control how I respond to things, but I can't always control what my immune system's going to do. It's a little funny. Um, so I went back on a cycle, right? And so when you have the dose that low, you can just cycle on and off readily. When you're taking, you know, a really really pronounced dose and you have obesity as a disease, you are probably looking at forever. And so it's a different way of thinking about things. Um, I don't know why everybody's so hung up on that though because they will easily accept a statin prescription or a blood pressure medication prescription and never even question it. And I could very very easily argue that those are lifestyle induced conditions as well. Like you got yourself to high blood pressure and you got yourself to cholesterol issues to some degree. Now again aging in inflammaging uh metabolic you we all become insulin resistant as we age. I'll give you an example. I had a friend of mine message me this morning and he said, "My dad is, you know, in his 60s or 70s and he's he's obese and
his 60s or 70s and he's he's obese and he's diabetic and his hemoglobin A1C is like 7. 5 and his doctor suggested Ompic." And I said, "Great. Put him on it." Like just go slow and low. Just as slow as you need and and keep it as low as you can. And like my dad for instance is the only person up until several months ago. He's the only person I dealt with who had really overt obesity. And everyone else, like I said, I was dealing with different conditions. Crohn's disease, a lot of gastrointestinal stuff. Um, a lot of PCOS in clients, depression, anxiety, brain fog, all kinds of different things. This was a truly diabetic obese person, my dad. And I still only got him to halfway up the standardized tier of dosing. We went so slow and we kept it so low that finally there's this magic titration point where the weight starts falling off and that's different for everyone. It it's lower if people are doing all the things. It's higher if they're not right. So we finally got him walking. We finally got him paying attention to some degree what he was putting in his mouth. And I was able just to get him up to a dose that I I feel is really comfortable. I'm I'm very comfortable with the dose. It's not the highest. It's not the lowest. But he's there and it's working for him. Right. So, I told this guy today, I said, "Get your dad on it. That's great. Just go slow and low." And then his next question was, "Will he need to be on it forever?" And I said, "Probably, because he's older and as we age, we become more insulin resistant, period, by default of aging." And and that's it. You know, no best best intentions aside, every single
best best intentions aside, every single patient I had that walked into their 80s all ended up with diabetic labs. Like, that's just part even if they were rail thin, that's just part of aging. And then his next question was, "Well, can he micro dose?" And I said, "No, for all the reasons I've already shared with you, he's probably looking at a much more standardized." I asked him how much weight he had on him that was excess. I said, "Well, how's his lifestyle?" He's like, "Well, he doesn't do a damn thing. He won't eat well. He doesn't exercise." And I said, "So, he's probably looking at a a higher standardized dose and it probably is going to, this is just my opinion. This is not medical advice, but I'm like, it's probably going to give him an extra 20 years. So, he gets to choose what he wants to do with that. they will definitely clear his brain and in a certain amount of time, usually about 3 months in, they really want to start moving. People really start feeling like moving and their brain clears out and they're like, "Oh, my instincts are turning on. I should probably take care of myself. What should I do now, doc?" And so, it's critical that health coaches and clinicians understand this is a team effort. This is just a tool. It's not monotherapy. It's not a it is pretty damn miraculous, but it's it only is as good as the input that you're giving the rest of the body and the rest of the health treatment plan. So, if people are going to take GLP-1s, it is my opinion, they get a few months of lag time until that brain fog clears and they feel like moving, but it is my very strong opinion they have absolutely no right to be on these or stay on these if they're not going to go to the gym regularly and they're not going to invest in a strength and conditioning coach or some kind of system or process to maintain muscle mass and build muscle. It's
muscle mass and build muscle. It's actually anabolic to muscle. It's actually protective to muscle and it's protective to bones. I just heard a big um exercise women's specialist exercise physiology PhD online. She's got a huge following and I heard her say Ozempic is going to turn your bones to dust. And I was like tell me you're literally not keeping up with the literature. Like that is such complete BS. These peptides are quite literally regenerative to muscle, bones, and joints. It's a matter of are you starving the patient? Is the client or patient being dosed into such appetite suppression that they're wasting? That's the problem here. And so I see no reason why people can't successfully be on them. And in fact, if they were to overhaul their life, what pharmaceuticals could we get them off of? So I'm not so worried about them being on them for life if I can get them off statins, if I can get them off of all the I mean, I the amount of people who messaged me. I have a huge online following and I get a ton of messages every day and people write me these novels telling me they always start out the same, like, "You saved my life. Thank you for being so brave."and delivering this message because I have taken a lot of heat for it. Um, people getting off of like three, four different anti-depressants, people getting off of lifetimes of medications, people being able to significantly decrease I I I'm not anti - pharma at all. Like my whole strategy with patients is people come in with a mountain of pharmaceuticals and their health, overall health is down here. My goal is to do this. So, I'm happy to
goal is to do this. So, I'm happy to prescribe and keep them on what they need to stay on, but I sure would like to get that dose as low as possible, and that's contingent on them doing all the things. But this peptide really gives folks a leg up to do all the things. Clinicians Corner podcast is sponsored by Restorative Wellness Solutions, the premier clinical training program for health practitioners who want to learn how to finally get to the root source of their clients health concerns and help them reverse complex health challenges and chronic illness. You can't afford to keep guessing. Your clients can't afford it either. Today's clients are sicker than ever before. Their health histories are more complex than ever before. And you simply can't deliver the results they crave or build the practice you desire without the right clinical skills. Enter Restorative Wellness Solutions foundational course, Mastering the Art and Science of Gastrointestinal Healing. Our clinically proven systematic approach to restoring balance within the body that has helped over a thousand practitioners transform their clients lives, grow their business, and change the way health is delivered. In less than 12 weeks, you'll develop the clinical skills and confidence you need to help your clients feel better faster. Learn how to work with advanced lab testing to identify food sensitivities and imbalances within the gut. Craft customtargeted protocols that truly resolve your client's gut issues and work safely and effectively with supplements to deliver consistently life-changing results. Visit masterguthealing. com to apply today. I want to talk about side effects because that is also the,
side effects because that is also the, you know, the big hairy monster in the room when we talk about these is these brutal side effects which of course, you know, if somebody is dosed so high that they don't have the appetite and protein tends to be the nutrient that they need the most and want the least. um how when we're doing at these more reduced doses, how does that impact some of those side effects? So, even if you're needing to get to a more standardized dose or a higher dose for more significant weight loss or more significant uh management of type 2 diabetes, you still can go really slow and low and the body acclimates pretty quickly. And so, that said, I don't have anyone having any side effects period because that's a dosing and management issue. We do not need to dose people into intense vomiting. and what you and I were saying offline. I've got so many of my colleagues and friends whom many of which I interviewed before I ever started talking about this. I called all my friends who I knew were using these clinically and I said, "Are any of you doing it this way? Are any of you using these tiny tiny little doses for all these other things like outside of appetite suppression, outside of weight loss, outside of type two diabetes?" And they all said no. They did say that they were using many of them were using the lowest dose in the standard dosing protocol. So just the regular starting dose or maybe even a little bit lower. They were starting people there, but they were using it as an on-ramping dose. So they might go lower for comfort to keep the side effects at bay, but ultimately they're using basically standardized dosing. Those same people are now coming out online saying that
are now coming out online saying that they're micro doing calling me and being like, "Why did you say you came up with this way of doing things that's unique to you?" And I was like, because I I'm hearing from their patients. Their patients are texting me because they're treating all these influencers and all these influencers are messaging me saying, "I'm on my couch puking my guts out for two weeks." But Dr. So and so said she micro dosed me. And I'm like, "Honey, you're on a standard dose. Like, you need like a fifth of that or maybe a tenth of that. Like, we got to go much much lower." And we're talking folks who have six-pack abs and are lean as a rail and super muscular, but as they age, their labs are starting to go sideways, too. like it happens, right? They're starting to get these elevations in lipids. They're starting to get some blood sugar dysregulation even with best of intention. So, a lot of folks are being told they're being micro doing now and they're not and they're having a lot of symptoms. And so, I hear from them and they say, "Well, I tried micro doing so sick and you lied and you you said your patients aren't having any side effects." And I'm like, "That's because you're not on a micro dose. You're just on a standard low dose. Might as well just call a spade. You're just on a dose." And so I don't think people need to be dosed into appetite suppression. We could just do appetite control. It does give you it it plays on dopanergic pathways in the brain and serotonin. And so it gives you back control. So a lot of folks say, you know what, not just the food noise is gone, the gambling noise is gone, the online shopping noise is gone, the doom scrolling on social media is gone, my chronic anxiety is gone, my I'm not micromanaging my team or my husband as
micromanaging my team or my husband as much. You know, if anyone's ever had a border collie, they like micromanage all the other dogs. Suddenly, they're like, "Oh, this is not my monkeys or my circus, right?" And so, giving people back, giving them that leg up and that onus of control. And then the other cool part is it induces neuroplasticity while you're on them. So, you're actually getting rewiring of the brain in the most beneficial way. What fires together wires together. And so, if we can induce neuroplasticity, exercise of course does that too. So, of course, we're exercising and we're stacking all the things that we need to be doing at the same time to really harness the benefits, but as you're inducing neuroplasticity, imagine while you're working with your clients or your patients, you're helping them instill these really beneficial lifetime lifestyle habits and you're wiring it because they've got neuroplasticity in their, you know, on their side for a time being. So, like if you're going to be on these peptides, don't waste the opportunity. Don't just fart it away by eating less of the same junk food and crossing your fingers and hoping for the best. Like, take the opportunity. Take that window of opportunity and change your life. Right. 100%. We have a lot of clinicians here who aren't prescribing physicians or practitioners who are going to be working with clients who have been presed by somebody else, right? How would you recommend they speak to their clients? Because they're dealing oftent times with a follow-up. And there's a number of different
And there's a number of different scenarios. You might find somebody who is working with somebody who claims to be micro doing. That's fairly rare. It happens, but it, you know, then there could be times when what's often going to be happening is that they're working with their primary who's put them on a standard dose and they're dealing with all the fallout of this. You know, our our starting point is digestive health. So, you know, the number of questions that I got about like, well, how do we deal with the slow motility and, you know, the heartburn that comes up and the constipation and, you know, and all of these additional symptoms. It sounds to me, and correct me if I'm wrong, but it sounds like if they were able to cut back their dose really significantly, even if they needed that clinically more robust dose at, you know, in the end, but to allow their body to accommodate along the way, they might not have all these things to manage. So, how would you recommend to them that they speak to their clients to get help with that dosing when the dosing is outside of their scope of practice? It's a complicated situation, but it's one we find ourselves in, of course, a lot, but I would love to hear your thoughts on how they can support their clients in this scenario. Well, it's getting very hairy because big pharma is in this ever lasting battle with compoundingies. And so to lower the dose, if someone's if the only access someone has is the pen, the brand name pens, those come how they come and you can't change the dose too much. In Europe, you can do a click. Maybe in the United States with WGO and OMIC, you can do a click method. Now, you can't tell your patients or clients to change their dose because only the prescribing doctor can do that. I can't do it online either and I won't. But it's always a 100% of the time the
But it's always a 100% of the time the dose is too high. So, that's just a conversation that you're going to have to empower your patients to understand. I have a beautiful course. I have a ton of free content. I have paid content and there's a whole module inside my big course all about how to find a doctor, how to talk to the doctor. But at the end of the day, it's the patient themselves has to become empowered through education. And they have to fight that battle. They have to become their own best advocate. If you're comfortable working with the doctors as a health coach, then you can get on the horn with them. But I found even as a n a licensed naturopathic physician a lot of MDs are not open to that having that conversation. Um so if we can move them to a compounded that's great because we can often play with dose there and get it much lower. I am all for the brand names though if that's what people can that's sometimes the only thing people can access. If someone's on the standard starting dose and they're still having a lot of symptomology. It's a kind of a waited out situation. It's unfortunate but it's sort of a waited out situation. And I'm, you know, I'm a naturopath, so like gut first as well. And so I'm all about the sodium butyrate and the ox bile and exercise. Exercise fixes a lot of gut issues, period. You know, um, this is where I love pulling out other peptides like BPC157 orally, TV500 orally, KPV, there's laazzide. There's a lot of different oral. They're expensive, but uh, they they really do help heal up the gut. I think though that if if you've got really like a little bit too much of these peptides is a lot too much. So, right, it can be that's a struggle. I
it can be that's a struggle. I understand that. And so, I am a big fan of the clinic, any of the folks. This is why I built my course is because I simply wanted it's for clinicians. It's for health professionals, but I let the general public in because I don't want to gatekeep the information. So, it's open to everybody at this point. And I just want people to understand these so well that you can go to bat. If you need to go to bat for your patients, you have the information. If your patients need to go to bat, you can arm them with the information. And I am a big fan of like I'll bring it with a I'll bring it with anyone who wants to argue with me on the data on this. So that's really what it comes down to is is empowerment. Um and just having those open conversations. I think a lot of doctors are hearing this terminology micro doing now. I think they're starting to hear it and it's we've got the journal of diabetes actually did a beautiful write up on it. A a very wellrespected endocrinologist just it was published I think in March 2025 and they were talking about using micro doing for type two diabetes and really I think at the end of the day what they were talking about is using it as an on-ramping strategy. So you know go starting lower and this is just a conversation about personal dosing. This is about inclusivity. This is about like why I wouldn't put a patient on any other medication and expect them to puke it out for a month before they acclimated. Right? So this is the whole point of compoundingies or when we can get medications that are standard pharmaceutical drugs that we get in tablet form or liquid form so that we can play with the dosing to what's tolerable for the patient. An example I'll give you is I've had patients who
I'll give you is I've had patients who absolutely needed an antibiotic like they had we needed an antibiotic and they there was pneumonia or there was sepsis or there was cellulitis or there was something that required an antibiotic and the standard prescription available tablet at the lowest dose was intolerable to the patient whether they were having like a Herxheimer reaction because the gut flora died off too fast or the medication itself like fluoricquinolones you know levbo um I mean um uh god I can't think it's like um cypro, what's the other one that starts with an L that's so popular? I can't think of it right now. They cause tendon rupture, spontaneous tendon rupture, all these fluoroquinolones. And so I'm going to put the patient on half that tablet. I'm going to say cut it in half and make it tolerable until we can get you up or maybe we just treat it with half a tablet. Like this is just good doctoring. So, I think when a patient comes in with education, they're empowered or the health coach is having a conversation with the clinician just being respectful and saying like, "Hey, we just we want this client on this medication or this peptide, but the dose is intolerable. What can we do to make it tolerable?" And I I feel like that's reasonable. Let's talk a little bit about compounding because there's I know the there's been all sorts of regulations and sort of, you know, access issues. So, is it possible for people to be able to get things at these really low doses? And I think that's a really good guideline. Just to reiterate what you said at the beginning, a fifth to a tenth of the standard starting dose. Just if people need some language and
Just if people need some language and and guidance in terms of a starting point to talk to your clients, to talk to their doctors. That's that's what we're talking about here in terms of the this like really low and slow strategy. It could be half though. You know, a lot of folks who So, let me mention something before we get to that. there. One of the one of my hypotheses when I started this was this idea of a functional deficiency meaning I mean how many people's guts are trashed right all of them every so my theory was well what if their L cells are trashed aging leads to intestinal atrophy chronic inflammation in the standard American diet leads to intestinal you know leaky gut intestinal atrophy what if their L cells are just shot to hell and what we're going to give them bourberine until their L cells take like that's just not always realistic. So my thought was why don't we supplement back in a tiny dose of what they may need just to get to normal. I wasn't looking at super physiologic dosing and this is how I do all hormones like this is how I do thyroid. This is how I would approach a woman who's 35 and having vaginal atrophy and she's rail thin and she needs a little tiny bit of estrogen because she's bleeding like a crime scene like or she needs some progesterone. I'm not going to hit her with the menopausal dose. I'm going to hit her with a little tiny little bit to get her back to baseline so she feels better and all of her symptomology goes away. Um, a migraine sufferer, I'm going to make sure we get enough thyroid in there, even if their thyroid labs are normal. I'm going to treat them symptomatically with the tiniest little doses. And this is a concept most
doses. And this is a concept most doctors do not understand. I didn't realize this until I came out talking about it and doctors started attacking me like this is not how they're practicing. They're following standard of care. They're following labs. I'm like to hell with labs. if we get your symptoms dialed in. My, like I said, my background was pain. I was predominantly trying to get pain down in people and what was the hormone cocktail that we needed to do that. We use labs to make sure they're safe. We use labs to cover our ass. We use labs to make sure we're not c causing any kind of overdose. You can have perfect labs and still be having a hormonal overdose. Right? So, all that to say, the GLP1's exactly the same. And that is my strategy with it. And it was this thought process of we have data to prove that those living with obesity and type 2 diabetes and fatty liver have a GLP-1 deficiency. They h they make much less GLP-1. And then we have a great study from a few years ago that showed when you took obese people, humans, and their lean counterpart, and you fed them both fat, they both released the same amount of GLP-1 in response. when you fed them both carbohydrates, the obese group secreted significantly less GLP-1 out of their gut than the lean group did. So that's fascinating. This is a functional deficiency and this is a concept that is nuanced and that a lot of standard alopathic doctors just cannot or will not wrap their heads around. And so this is where the conversation gets challenging sometimes is because I'm over here saying, "Yeah, but I gave them a tiny bit of this. We're not causing any harm. It's such a tiny little insignificant dose. It's literally a droplet and they feel so
literally a droplet and they feel so much better and all their joint pains better and all of these symptoms have resolved and we're doing a lot of other things. We're not just doing it in isolation and you're telling me that that like that's not a good way to practice. That just seems silly to me. And so, um I I lost your question in my rant. What were what was your original Well, my question was about um was about compounding. Oh, yeah. Compounding and the access to these kind of these I I love everything you're you're saying here. This makes so much sense. So, a lot of these doctors will not get behind compounding and I they just won't do it. They will not prescribe a compounded medication because they think that it puts their license at risk and it might actually at this point. And so, big pharma has been at war with the compoundingies and it's getting very heated. And what's happened is just so people understand compounding GLP1s is not going away. 503b there's 503A compoundingies and there's 503b. And what 503b is is it was an Obama era Obama administration era solution to drug shortages. They said, "Look, when we're having a shortage of something, we are authorizing these 503b compoundingies to mass-roduce this medication." And because these brand names have been on shortage for so long, 503bs were in full effect. and they were making and and from what I've heard, I'm not a compounding pharmacist, but from what I've heard, sometimes even in similar manufacturing facilities, like very high quality, very to standard, you know, sterile injectable prescription,
prescription, but not the same exact as the brand name because that's on patent, but very damn close. Now, what's happened is they shut down the 503bs. That's what this these lawsuits have been. So it's going back to the 503As and what I have seen is it's this means that the actual pharmacy itself is responsible for creating this. So they have to have the big hoods and the walk-in hazmat type level of sterile injectable. It's a big or undertaking. So not all compoundingies have this and not allies make injectables and we don't always know what we're getting. Yes, we would hope that they're all being very careful and sterile and good, but in the past, as an injection therapist, I can tell you that there has been some problems here and there with different far compoundingies in my entire career. I've seen like one or two times where there was some bad batches. Um, so that is a little tiny risk. It's very rare, but access is going to get harder. It's going to get harder and more expensive. And so when I went to refill a prescription for a patient the other day, it was like three times more expensive than it had been two months prior. So now this patient and I are working on getting their primary care physician to prescribe the pen because this person's on more of a standardized dose at this point. And so because they do have some weight to lose and so now we're like trying to figure out which is less expensive. So I think co it's going to become more cost prohibitive which is very unfortunate. The a lot of the dosing that I had folks on when we had
dosing that I had folks on when we had 503bs going it was so inexpensive. I had people on like $ 30 a month. Wow. That's not anything of the like $ 1, 500 $ 1, 600 a month that you hear because a vial would be like a hundred something bucks and it would I mean you are supposed to they have a shelf life but they often work past that. That's up to your risk tolerance with your patient. I'm not giving any place there. I have the risk tolerance and I'd have the conversation with the patient of what we were doing. Um, but that said, very often these doses were $ 30 to $ 50 a month and that was allowing them to get off a lot of other pharmaceuticals and a lot of supplements. That's the other thing. These supplements, I mean, God, people really end up on a massive expense of supplements every month, which I think is fairly unethical. So, they're trying to go the natural route. And I'm like, honey, we got something over here that it's like, you can take your $ 60 a month thyroid, but I have also prescription thyroid desicated that's a lot cheaper. So like you got to work with your clients and figure out what works for them. So that's the story with compounded. It's not going away. It's just going to become like everything unfortunately less accessible which is too bad. I I really think if big farmer were smart they would have they do have the vials now. You can get brandame tzepide and brand name named saclletide in a vile form but now big farmer has done some kind of funny thing where you have to use it all up in a certain amount of time or you don't get the price break on it. So they're making it very difficult for people to afford these. And I think if they would just listen to me and stop fighting with me. Um I'm talking about inclusivity. I'm talking about access
inclusivity. I'm talking about access for people to have medications that are life-changing. they can sell all the I'm making them a lot of money. I'm not a shill for them. I don't get any checks. They they come at me and I'm like, "No, I'm making you guys money. I'm trying to figure the benefits of this out." So, what do you think this is about? I mean, we kind of hinted at that at the beginning, and I really would love to understand why they're coming at you because it seems like if anything, what you're doing is helping to assuage the fears, helping to talk through strategies that will ultimately have even more people use these use them maybe more strategically and not in such, you know, so just one sizefits all type of strategy, you know, for these different purposes. I I don't understand what why do you think what's your theory on why they're so against Well, I'll tell you one thing first. There's in hormone land, there's receptor resistance. Like receptor resistance is a real thing. And so I cycle everyone's hormones. When you're doing estrogen and progesterone, for instance, we take a week break. When the menstrual cycle happens or the period, we when menes happens, we I give them a hormone holiday, right? I say take a break so that those receptors reensitize and they will listen to whatever it is we're providing it. If we give somebody crazy high doses of testosterone for instance all the time, like a take a male patient for instance, they're going to ultimately get receptor resistance and we have to keep upping the dose, right? And so that's a problem and that's a problem with peptides as
and that's a problem with peptides as well. And so I that's why I suggest cycling going on and off and that's strategic. That's different for everyone, how long someone goes off. There's no cookie cutter response to that. I go into my strategy around it deep inside my course, but there's a lot to think about. And I think that's a real problem with some of these more traditional dosage strategies that are very they get people ramped up very quickly. So they virtually double the dose every month for 16 weeks and they get people say on the starting dose of semaglutide is 0. 25 milligrams. They ramp them up to about 2. 5. Wow. Super fast, right? And I'm thinking, why would you guys do that? You're these are going to stop working. And they are stopping working. I'm hearing from compounding pharmacists who's got who've got patients calling saying, can we go up? It's not working anymore. I just talked to one of my buddies who legitimately struggles with extreme obesity. And he called me and he's like, I have been on the highest dose of Trzepatide forever. It's not working. All the weight's coming back. All my labs are going back to abnormal. like all of the problems he had before he started THR appetite are happening again and he's on 15 milligrams a week which is a crazy high dose and I'm just like this is not sustainable we are going to see a massive fallout from this and if people are not lifting weights and eating meat they are going to have a massive fallout metabolically they're losing their metabolic engine and they've got receptor resistance and so the solution is oh let's make a new like there's a new one coming out that's a triple agonist and everyone thinks this
triple agonist and everyone thinks this is going going to save the day and I'm like not if you're not doing all the things and so right I don't know why there's a problem with big pharma on that but I will say with the general public this has been a very interesting run um I think there's a lot of fatophobia and I think there's a lot of obesity bias and I think there's this very outdated I want to it's like 1982 called and they want their obesity strategy back this whole like eat less and move more yes that's part of it and yes eating nutritionally dense food in my world is non-negotiable if you want to heal GLP-1 or no GLP-1 and going to the gym and really strategizing muscle above all else is non-negotiable if you want to live a healthy life and you want to not break a hip when you get old like GLP1 or no GLP1 but if you're on a GLP1 I think these things become far more important and non-negotiable and I think there's a whole group of people including influencers who have something to sell you I just saw a huge online influencer a chiropractor he loves to bash ompic he loves it that's like his whole thing. But he'll he came out the other day and said, "Oh, BPC57157 saved my life." You know why? He can sell it to you in a pill form. He can give you an affiliate link and you can access it without a prescription, right? Like that's the only thing I can think of that these folks have something to sell you. It goes against what their program offers. It goes against what their business model is. I don't know. But I am beyond grossed. Like I have severed I can't tell you how many this has severed more friendships for me than co did
co did because I can't believe how intentionally ignorant especially with as big of a mouth and megaphone as I've had on the topic. Like how can they be so intentionally ignorant? Like show me that you do not know how to keep up with data. If you're a physician and you're bashing on these peptides still you clearly do not know how to keep up with the data. And if you're a health coach or a strength and conditioning coach or anyone else out there they are not going away. So you can bash on them all you want because it can you're you live in you know this whole like world of it's like the opposite of in my world it's like let's just build a bigger pie and let's support people because people are going to be on them right like one in six Americans has used GLP1s. People are going to be on them. So if you're in the health space, figure out how to support them, but living in scarcity. And I mean, I hate to say that, but it's like I think that's why so much push back is happening. And then there's just very interesting um I'm just going to say it there. I have watched many of my very lean girlfriends have a very strong opinion about it. And I'm like, well, are you worried about competition, honey? Are you worried that like you know I lived as a I have lived my whole life as a very thin woman in a family of very obese people. I understand thin privilege. Are you concerned about that? I don't know. And then in the other part I I think this is a very valid argument actually. I have talked to several people in the health at every size community and they're like, "Look, we have fought so hard and so long for acceptance and to stop being
so long for acceptance and to stop being shamed and to stop having people judge us based on our weight and now you're telling us you want us to be smaller again." Like, and I can see how that's I mean, there's a lot here and I'm not judging anybody on either side. I know there's a lot of emotion and there's triggering that goes on and but all of it culminates into this just eat less and move more and obese people are just lazy and they don't need help and I'm like no there's actually a disease process happening here these folks do not have the same sometimes they don't have the same signaling those signaling peptide hormones they don't have the same signaling other times they don't have the same reception so they're not hearing it no matter how much you put in the system the brain's not hearing it I'm not judging like that is to be sorted out. And these peptides are complete game changers for such a huge percentage of Americans. It seems very shortsighted, especially the maja movement. I've been shocked and disgusted with how flippant and dismissive they've been. And RFK paring the words of Cali Means and I were in a debate and I corrected him multiple times and yet he continued to go out on the circuit and spread misinformation about these peptides and this fear-mongering and scaring of people. They they claim in that community that they're it's going to bankrupt America. And I'm like, actually, so is obesity. So, we need to and so is cardiovascular disease. We have data that came out in 2024 showing protection against cancer. We have a ton of data that came out in 2021 showing
of data that came out in 2021 showing protection against COVID, significant protection. So my argument is like who has something to sell you that they don't want this GLP1 to get in the way of their bottom line. Well, we all have those clients who come and they are doing all the things right like they really are doing the work and things are just not moving and I really see that this can be such a game changer for them. I'm super mindful of time. I have two more questions for you. So number one is contraindications. Are there certain people who should not be doing this? And are there things as practitioners, if our clients are on this that we need to be like, okay, now that we know that you're on this, we need to make like there are certain maybe supplements we shouldn't recommend. I mean, I think we're we're all aware that dietarily we really need to focus on protein, we really need to make sure that that what that even if their appetite is suppressed, what they are eating is very nutrient-dense. I think everybody's clear on that, but are there any kind of contra indications that they need to be aware of when their clients are on this or are who are people who are not candidates for this? Yes. So, for the sake of time, I have a free four-part video series and I think it's video two where I break down all the big scaries. So, I really want people to go listen to that because that has all been misrepresented. There is not an increased risk for pancreatitis. The the literature is just not bearing out there. There is not an increased risk for thyroid cancer. The literature is just not bearing out there. And there's better more comprehensive literature that's come out since I recorded those videos. So I do think
recorded those videos. So I do think there is a real concern with biliary issues. If you you know and who has biliary issues your 40-year - old female who has a little bit of weight to lose, right? Like we have we like that's the phenotype and that woman's probably the woman who needs a GLP1 the most and yet she's at the highest risk for gallbladder. The pancreatitis comes when you throw a gall stone into the pancreas. So if you starve somebody, if they're on such an incredibly high dose that they lose their appetite completely, they stop eating and all of their paristalsis gets sluggish and their bile in their gallbladder gets sluggish and everything slows down and then they go and crush a Chick-fil - A because they're not being mindful of the foods they're putting in their mouth and they go I really think the fatty fried foods are problematic. Like stay away from those if you're on a GLP1. Whether you're doing a tiny dose or not, you will want to puke after you eat fatty fatty fried foods. So just most of the crap you shouldn't be eating. Um that can really put her gallbladder at risk and she could throw a stone and get pancreatitis. So that it's not the p it's not the peptideinducing pancreatitis and melting your pancreas. It's the gallbladder issues. So support digestion. That's why I said ox bile whatever your favorite you know bitters are support digestion. Make sure that they're getting paristtoalsis going. Absolutely need to be pooping once a day. Like non-negotiable, right? whatever that takes to get the poop going once a day. We need a bowel movement. Uh especially I do think hormone replacement therapy, I will say these peptides even at tiny micro doses will unmask hormone deficiencies. And so I've heard from and seen several women
I've heard from and seen several women directly who even on the tiniest dose all of a sudden started having significant hair loss or the lateral third of their eyebrows, you know, fell out because they were sitting on the edge of hypothyroidism or they were sitting on the edge of pmenopause or menopause and the peptide sort of unmasks it. And so HRT is really critical, but we're not giving estrogen to a woman who isn't pooping every day. So you see how this all we got to support the gut first. I'm gut first always. So I like that approach of what you said. Um, and plus if there's lipopolysaccharides like cranking through their system, that's going to glom up their liver. So I do think a lot of the big scaries are a dosing and management problem. And if you have a history of biliary issues or thyroid cancer, obviously you should be working. Don't go to a med spa. Don't go to some fly by night tele medicine company. like work with someone intimately to hold that will hold your hand and help you. Work with a health coach. That I think is also non-negotiable. Like work with somebody who can help you through this part because the foods you're choosing to eat really matter here. Um and then I think that supplement wise, like I said, I love sodium butyrate because that's anytime we can stack the L cells actually making more GLP-1. So I know there's an ac couple acromancia products out there. not a huge fan of like high dosing a probiotic but you know intermittently I think can be helpful. Sodium butyrate is going to help with digestion but it's also going to help get the L cells to make its own GFP1. So I'm looking to because there is some studies out there and they're hard to find but this was on laglutide and this was standard dosing but it did actually shut down endogenous production of GLP-1. It
down endogenous production of GLP-1. It significantly reduced it. So this is another reason I say go as low as possible. And the only way to keep that dose low is they have to be doing all the other things. So this is incentive for them to actually get their ass in gear and take care of their health overall because we don't want to shut down indogenous production because then they are going to be on it forever. Right. We want to keep those L cells. We anything that's going to heal the gut is going to help the L cells out. Um what was the second part of your question? Did I cover it? Well, you covered that. What's really interest Well, I was talking about supplements, but I actually want to dovetail because you already dove you already touched on something I wanted to ask next, which is there's this kind of idea of nature's ompic, right? And you've already talked about a few of these different things like the acromancy, these these things that stimulate the body's own production of GLP-1. That is not what we're talking about here. Like, it's not enough to do that, is it? Right. And can you speak to why? Because that there's a lot of that's another thing I see from a lot of influencers is like you don't need to be doing any of the GLP1 no matter what the dose. you just need to be stimulating the body's natural production. Can you speak to that? And I love that you just talked about stacking it. But yeah, just carnivore, it'll fix everything, right? Um carnivore, you know, some of these diets, these extreme dietary diets can actually like high arachidonic acid and saturated fat will induce insulin resistance in a lot of people. So, you're actually like shooting yourself in the foot there. So, I think a balanced diet, getting enough fiber, um making sure that you're eating a variety of things that are interesting for the gut microbiome, and then we you you need like bourberine would need to
you need like bourberine would need to work about 600% better to stimulate the L cell. So, we're stacking. We're just trying to nudge the cell to be like, "Hey, wake up." But it's not just that. We're trying to heal the gut. I think that's the overarching thing, right? Like I'm just thinking like how do I decrease the pathogenic organisms to stop shooting off the LPS and how do I get the gut to calm down and actually start working the way it should and get the digestive juices flowing. One of the best ways I think really is exercise, right? Stress reduction, making sure they're sleeping, all the things like all the non even if there weren't a GLP1 on board, this is still my treatment plan for every patient. And then we are just trying to get digestion to be supported overall. And I don't think it's not that I don't think there is absolutely no nature's ompic. That's like saying that there's a supplement that mimics insulin. That's ridiculous. It's like people saying, "Oh, I take this herb and so therefore my estrogen is I'm" I'm like, "No, there's no estrogen replacement that isn't estrogen." I get that question all the time on social like, "What can I do instead?" And I can't tolerate it. I'm like, "Well, I don't know because there's nothing that is estrogen that isn't estrogen. So there's nothing out there that is a GLP-1 that isn't a you know it come in a peptide form. So we just want to we want to support the individual in all the ways and then we're using those to kind of nudge them. But don't overdose your patients on supplements either. Like if they need a GLP-1 that's going to be the probably the least expensive route to go. Yeah. It's fascinating. Um I have like there's so much more that we could dive into. I want to be sensitive to time. Um,
Um, shoot shoot me a few more. I got a few minutes. You have a few more. Okay, then let's keep going. Well, one of the things because we're talking about gut healing here and we're talking about supporting the gut. We definitely there's a lot of folks whose clients are on the higher doses and who are experiencing a lot of that gut stuff. So, they're going to have a conversation with the prescribing physician and see what they can do about that. In the interim, what are some strategies? you know there for example if somebody has you know they're on a a protocol with eradication agents and maybe some binders and these are things that like we want to make sure that the you know everything the gut is moving. We certainly don't want to exacerbate any kind of constipation but recognizing that there is that slower motility when we for example dose things away from food normally we're thinking you know 90 minutes after eating 30 minutes before the next meal. Do we need to adjust some of that thinking when we're thinking about some of these gut protocols if the motility is is really slowed down because of being on too high dose? I think it can really exacerbate SIBO for sure like a thousand%. Um I that actually happened to me. My SIBO got I was like oh my SIBO's getting worse and I could tell because I was getting I wasn't even getting gut symptoms. I was getting like puffy under I was getting histamine symptoms right. I was right. So you cycle off and you clean up the gut and yeah that's a problem. This is why we I mean I don't have a solution because the answer is to keep the dose as low as you can so that you can easily cycle off. I know people that have taken
cycle off. I know people that have taken kind of mid you know what is that dose? I think mid-range, but you often have to titrate people down and it can get messy. And so folks who are on very high doses are definitely if their gut motility is stalled out, they are definitely looking at exacerbation of SIBO and other, you know, overgrowth of pathologic organisms and that's problematic. And I I don't have a solution except to remove the offender and right clean up the gut. There's not I mean there's not a trick to that, right? Okay. Well, that's actually really that's really helpful advice. Um, a question that I had asked earlier that the part two to that, let's return to that. Are there supplements that if that should not be consumed at the same time as somebody being on a GLP-1? No, but I do want to be cognizant of some of these natural, you know, ompic. I think someone blasting bourberine all the time is really going to create a lot of potential um, imbalance in their gut. The cool thing about GLP1s is they and a great study just came out literally like this month. It was just published showing and I this has been my hypothesis and we have some data showing this. It it shifts the microbiome and I think one of the reasons people have such a hard time going on it if they are on a more standardized dose and they get so sick is because it shifts the microbiome to a much more favorable microbiome and we get the good bugs in there and there's die off of the bad bugs. So I think a lot of people's side effects is actually just them herxing. I think they're they I call it the purge. It comes a few days after your first dose and it can last a few weeks after
dose and it can last a few weeks after every time you take a shot and all of a sudden a lot of people get don't get constipation they get diarrhea when they're on these and so it's just a matter of like what's their gut doing? What's their special SIBO cocktail in there and ultimately though interlucan 6 goes down TNF alpha goes down um all of the inflammatory markers decrease on GLP1s. This was in a mouse study, but it did show significant improvement in shift in gut microbiome. And so, we know that's happening. Another reason to go slow and low, right? Another reason to work with them because you could potentially use that to your advantage. And I do. I clear their SIBO with it. I'm like, "All right, great." Like, we are definitely inducing a more favorable microbiome in here. What can we do to support that along the way? And, you know, do we need binders? Do we need bofilm busters? Like, whatever order you like to do that in. I kind of like to do it all at the same time, honestly. And I like to throw in my antimicrobials along with it and just kind of like teeter it to symptomology and get them where they need to go and then we can ramp up the antimicrobials, but we obviously can't stay on those forever. So, whatever your favorite protocol is, take advantage of that window. If they are doing it slow and low, if you have someone who wants to go on a GLP1 and they haven't started yet, this is a time to convince them like really make that sale that we need to double down on getting your gut prepared and getting the foundations prepared. And I go all into all of this in my course just not in depth like I don't go into in-depth treatment plans, but I go into my methodology because I think this is a really great chance for people to like when people message me
people to like when people message me and say, "I want to go on a GLP1 and I don't know what to do." And I'm like, "Go to the gym. How about you start making a three time a week habit of going to the gym before you even start a GLP1?" Take this as a window of opportunity to get serious about all the other things that you need to be doing in order to be live a healthy, you know, metabolically sound life. And then the GLP1's sort of the frosting on the cupcake, if you will. Yep. Something I think is just so reinforcing here and validating, and I hope everyone who's listening live right now is feeling this is you're, you know, the starting points are all the things that we focus on, right? Like we're really optimizing that gut. We always talk about starting with the gut really in everything. We're looking at and identifying sources of inflammation, trying to minimize those. We're trying to like balance as much as we can balance with the tools that we have. And I love the way that you talk about this is that just that little finishing piece like kind of like the bow that like ties it all together. Um, also what you're describing here in terms of all of these inflammatory markers that are downregulated and some of the healing benefits with it in the gut. This makes sense of why you're seeing such good results with things like autoimmunity. Yeah, it's and this is why I think slow and low is the strategy because what is the dose that that individual needs to get the benefits that they need and what are those short-term goals and what are those long-term goals and you you get it. I'm speaking at the World Peptide Conference this coming weekend and my whole talk is like these are all the things you have to do to make the peptides work or they're not worth a damn any peptide, right? And it's all and the whole thing goes back to the gut. Like that's how I'm finishing the whole talk is if you don't treat the gut
whole talk is if you don't treat the gut first like naturopathic 101, you're not going to get very far, honey. So anyway, I didn't mean to cut you off, but um yeah, it's I think it's just a really beautiful it's really it's just adjunctive, right? It's just it's all the tools. It's all the things we have. Anybody relying on it on a high dose as a monotherapy, I do believe is going to get in trouble eventually and they need to learn how to titrate down. I I just I don't think these crank and high doses are sustainable. And right, whenever anybody has shows any interest in it, if anybody even wants to go to a functional medicine doctor and pay thousands of dollars to go work with a functional medicine doctor, I'm like, "Start with a health coach and get your together." Like, I don't have a nicer way to say it. Get your together. And if they're not interested in going to the gym, I'm like, "Too bad. This is not I'm not asking." Like, you have to get these pieces in play to be a healthy human being. And this is just how it is. So, do the pieces. Establish the habits. if you need help with that, like there are a lot of people who are very inflamed, they're very sick, they're very autoimmune, they're very obese, whatever you whatever. And often that the GLP1 can help them get that leg up to get over that hump and to really start moving in the right direction. So, we give it early, but it's like the carrot. If you're not going to do the rest of the things, I'm taking the prescription away. And then there's the other people like ourselves who've done all the things and some the wheels are starting to fall off the car for some reason and we don't know why. We can throw a little I really think ad, you know, adverse childhood events are severely underappreciated and I can't help it if somebody went through a
help it if somebody went through a lifetime of abuse as a child and now they're manifesting severe disease processes from it, but they're thin and fit and they're eating like a champ, but things are going sideways, right? We give them a little GLP1. It's very, you know, it's different, but it's the the foundations are never different. The things you have to do don't ever change. And this is where I think having a good health coach on board, good strength and conditioning coach or even a small group uh strength there's there's various entry points economically to find these resources, right? I know socioeconomics matters here and I want to be respectful of that. But there are like for my elderly folks who really want to try a small dose and they're scared of the gym like go join a silver sneakers. You know, there's there's entry points into what you need. It's just a matter of finding it. And I think the best thing we can do for our clients and our patients is to be an advocate and to help them find and I'm just a cheerleader. Like I'm not holding any magic wand. I'm just cheerleading them on. And I have a good way of putting things together in my brain. And I love treating people as individuals. Like I'm not treating diseases. I that's the other thing I want to be clear. None of this is treatment, prevention or cure. This is longevity. This is me treating a human being sitting in front of me with a myriad of symptom picture and I'm just trying to get homeostasis back in line. Right. and the work is on them. I just come up with the ideas. Um, I'm sure after listening to this, if they already weren't intro interested in
they already weren't intro interested in these really tiny doses for themselves and their clients now, they are how do they find somebody who can do this properly? I know that there is a lot you know there's a lot of confusion let's just call it nicely in the industry around this as you said some you know well-intentioned people are calling things micro doing that are not remotely micro doing is there I know you're you're thinking about doing more in-depth training for licensed practitioners in the absence of that while we're waiting for that how do they find or what are some questions they can ask to help understand if the person is doing this really truly micro doing I think they first Just first of all, find a doctor who lifts weights. I think that's a good start. Look in the longevity space, the cellular medicine space, the regenerative medicine space. That those docs tend to be more savvy. Um, you're probably going to have to pay out of pocket. Although I don't I know many people inside my program who about half of them are clinicians and the other half are general public and they're finding success. We have a whole module in there on how to do this, but they're finding success. They're like, "I just learned a lot and drilled on my doctor, my general GP until he finally gave it to me." You know, like patient empowerment is a big deal. So, you knowing as much as you possibly can. I have 20ome hours of free content on my podcast. I have a free four-part video series that'll give a ton of education. A lot of people just went with that and have found great success that way. But it comes down to you knowing your stuff. Inside my course, I actually give you access to the document of like 40ome
access to the document of like 40ome pages of all the studies. So, literally any condition. It's organized by condition. If you have the condition, you've got 10 studies to bring to your doctor to have a good educated conversation with them. And I think it's just being an advocate for yourself. Finding a doctor who's willing to work with compoundingies is huge. If your doctor vehemently opposes compoundingies, you're you might have a hard time finding that dose. Although, I know many people who that's all they could get was the standard pen, the brand name, and the standard starting dose. And maybe they had a little nausea on the beginning, but it worked out great for them. So, that dose may be the most appropriate. I want to also add there is something happening with those doctors who are just hellbent on only micro doing. There's a whole subset of this happening now where there's doctors who are just just they will not even go to the standard starting dose. They're so hung up on micro doing but these people have moderate weight to lose. And so I see these people I'm like haven't you been micro doing for like nine months? You still have like 40 extra pounds and your blood sugar is all screwed up because of it. and they're like, "Yeah, they just won't give me a higher dose." And I'm like, "That's not good either. You the dose is individualized to the person and what they need." So finding it's tough. I I wish I had a better answer. It's tough. And I think it comes down to I feel even more strongly that education is the key here. And that's what I'm trying to build out inside that program. It's just like any and every angle that we need to cover because it's the like I said, the inmates are running the asylum on this conversation. down. Last question. If you could wave your magic wand and this this world was the
magic wand and this this world was the world according to Dr. Tina, um what would that look like? I think everybody would just have a really profound appreciation for what their body could do with a ultimate desire to optimize that and see what's possible. And a lot of that comes through movement. I think really getting in touch with your body and knowing what it's capable of and finding strength, physical strength. Um, and just honoring physical fitness. I feel like we've lost that as a culture completely across the world. And those folks in my clinical practice when I do regenerative injection therapies, the ones that I can like wave a magic wand and say, "I guarantee you're going to have phenomenal outcomes, "are the ones who have adequate muscle mass. Even if they eat complete and drink Red Bull all day, they have profound healing benefits when I treat them. And so just understanding that when folks like Gabrielle Lion and myself say this is non-negotiable, it truly is. Having a having and sustaining a level of physical fitness is in my opinion truly the only way through. Yeah. Brilliant. Well, we will make sure that we get links to that four-part video series. Um any links to your course, your podcast, all of that kind of stuff. Um can you just share where people can find you who are hot to trot right this moment? Sure. So the everything's at Dr. Tina D R T Y NA Tina with a Y. And so that's Instagram is where I'm most active. I'm on YouTube. The podcast is the Dr. Tina show. Very original. I was trying to
show. Very original. I was trying to make it easy. Um every Yeah, everything. My website's drtina. com and then drtina. commpic uncovered or just go to my website and it's the top banner there. That's the free four-part video series. There's a podcast tab. It's by category. There's a whole Ompic uncovered or GLP1 uncovered. We changed the name because we don't want to get in trouble with Nova Nordisk. So yeah, there's a whole ton of free education where I cover studies, the latest and greatest, and um I think that'll get people really far without paying a dime, right? I love it. Thank you so much. We've got so many requests for part two, so we'll see what we can do, but this has been invaluable. Um just so much fantastic information. Um I did a ton of research for this and I thought I knew a lot. I've already kind of blown my mind with what I what what I've learned. So, thank you so much and thank you everybody for uh for joining us today. We I we don't have the numbers, but I think we had probably the fullest house we've had. So, thank you so much. This was wonderful. Thanks for having me. [Music] [Music]
Transcript auto-generated by YouTube. Verbatim — duplicates intentionally preserved.
GLP-1 medicines have become shorthand for weight loss. Dr. Tyna Moore asks for a wider frame. In this conversation, they are discussed as metabolic tools: compounds that affect appetite, blood sugar, inflammation, behavior, and the biological terrain that determines whether recovery can happen.
That distinction matters. A tool can be useful and still require respect. The question is not whether GLP-1s are good or bad. The better question is whether the person, dose, monitoring, and goal are aligned.
Moore keeps returning to cardiometabolic reality: insulin resistance, chronic inflammation, poor muscle quality, disrupted appetite signaling, and the long arc of modern metabolic disease. GLP-1 signaling sits inside that system.
In plain language, these medicines may lower the volume on hunger and improve glucose handling, creating enough steadiness for a person to rebuild habits, nutrition, movement, and muscle. The felt result can be less noise around food and more capacity to act with intention.
The strongest theme is personalization. Moore describes a clinical philosophy that favors the smallest effective intervention, adjusted to the person rather than forced into a standard story.
That is not a protocol for the reader to copy. It is a principle: powerful therapies deserve careful dosing decisions, clear monitoring, and a clinician who understands the whole body, not only the scale.
Weight loss without strength is not the goal. The conversation repeatedly points back to lean tissue, protein, resistance training, and metabolic resilience.
Muscle is where glucose is stored, movement is expressed, and longevity becomes practical. When appetite changes, nutrition has to become more deliberate. The body needs enough raw material to repair, adapt, and stay capable.
The discussion also touches gut motility, bile flow, liver support, and microbiome strategy. Slower digestion can be therapeutic for some and uncomfortable for others.
That is why symptom tracking matters. A calmer appetite should not come at the cost of ignoring constipation, reflux, biliary symptoms, or nutrient gaps. Good care notices the tradeoffs early.
Used well, GLP-1 therapy can be a bridge back to agency. Used casually, it can become another outsourced promise.
The difference is context. Metabolic health is built through signals repeated over time: food quality, strength, sleep, stress regulation, sunlight, recovery, and medical care when appropriate. Medication may support that process. It does not replace it.
The body changes through signals repeated over time.
Discuss GLP-1 therapy with a qualified clinician who can evaluate metabolic history, medications, symptoms, and goals.
Protect muscle while appetite changes by prioritizing protein, resistance training, and recovery.
Track digestion, energy, strength, and mood alongside weight so the signal stays complete.
