Tirzepatide, Fat Oxidation, and Metabolic Context: Full Transcript

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0: 02 You are tuned in to the Dr. Tina Show with Dr. Tina Moore. For more, visit drtina. com. Hello and welcome back to the Dr. Tina Show. I am very excited about this episode today. A recent study has come across my desk that I wanted to share with you. I was first alerted about it by some of the big obesity docs that I follow on social media and they came out and had one opinion about the paper. So, I looked up the paper immediately, of course, and found that you had to access it behind a payw wall and it was quite long. So, I went ahead and paid for the article so that I could read the whole thing because the title is a little misleading and the key highlights are a little bit misleading. And so, I wanted to make sure that I read the whole thing, digested it, worked with the information, and I'm going to present it as I understand it because no disrespect to these docs, I respect them very much. They're obesity docs. I'm not, but I do understand metabolic health really well and I don't think they're getting the whole story straight. So, let's jump in. All right. So, first of all, here's the study. Tzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation. That's the title. It's in cell metabolism clinical and translational report. Just came out May 2025. Here it is. All right. See if we can focus in on that. My camera wants to be picky. So, what did this study show? I'm just going to read the first part, first page, so you guys can gleam what I think most people are gleaming from it. First, they looked at

1: 32 from it. First, they looked at preclinical mouse experiments and then they did a phase one clinical study on 55 humans. Very small, 55 humans. Doesn't tell us a tremendous amount, but hey, it's it's what we got. The highlights were in caloricrestricted obese mice. So these were obese mice who had calories restricted from them. Tzepatide attenuated metabolic adaptation. I'm going to get to what that means in a minute. In people with obesity, trozepide did not impact metabolic adaptation. Tzepide increased participants fat oxidation, decreasing sleeping and 24-hour reer. And trazepide decreased participants calorie intake at lunch and dinner by reducing appetite. So here's what the obesity docs online had to say about it. They said, you know, we're hearing our patients tell us that they're taking Trzepatide and that even though they're not changing their caloric intake, meaning they're not decreasing their calories, they're still losing weight. Is there some magic way that this peptide is working? And these obesity docs concluded from this paper of 55 people that no, there's no magical metabolic impact. It's literally calories in, calories out. It's due to the caloric restriction is why they are losing weight because of this highlight here which I already read turns appetite decrease participants calorie intake at lunch and dinner by reducing appetite. So the belief out there is that calories

3: 00 So the belief out there is that calories in, calories out is the holy grail. And I'm not saying that these docs believe that only, but that that's the going belief in the world. And that these peptides only work by reducing calories. That they're self - starvation peptides. And because you eat less, you lose weight, and that's it. End of story. Case closed. If you've been listening to me for any appreciable amount of time, you know that's completely untrue. They work on your metabolism in a multitude of ways. Most notably, they decrease inflammation in the body. They improve insulin signaling on both sides. Insulin production, insulin reception. They increase the AMPK pathway. They stoke it, which is going to help with mitochondrial health, which is ultimately going to translate into metabolic health improvements. So, we've got a lot of different mechanisms at play. There's more than this. You know, there's impacts on the brain. there's a decrease inflammation of inflammation in the brain. Uh there's various mechanisms by which GLP1s impart themselves on your metabolic health overall. It's not just about calories in calories out. But they looked at this study and they decided that because there was no metabolic adaptation change in humans even though there wasn't mice that therefore no metabolic impact. It truly is a calories in calories out thing. That said, they're still amazing peptides. I want to break down what all this means because I think they're wrong. I think there is a very protective mechanism on the metabolism going on here. And I want to explain to you what these terms mean

4: 30 to explain to you what these terms mean and how this works so that you understand that I think this paper actually proves that they have a really profound impact on our metabolic health overall beyond what caloric restriction would do on its own. Okay. So to truly understand this paper, we first have to get some terms out of the way and we have to understand what they mean. I want to explain what metabolic rate is, what resting metabolic rate is in the first place. So this is the number of calories that your body burns at rest just to keep you alive. That's your resting metabolic rate. All right? This is your breathing, your heartbeat, your, you know, blood pumping, all of it, digestion, etc. Your resting metabolic rate, RMR is what we're going to call it, is largely driven by your lean body mass and to a lesser extent by your fat mass. This is why I'm always banging the drum that you have to lift weights, that it's non-negotiable. Because when you lift weights and you add muscle to your body, you add you you increase your resting metabolic rate, which means you get to eat more. You burn more calories just sitting around on your ass than you would otherwise. So, we lift weights so that we can sit on our ass when we want to and not worry about it. You don't get to sit on your ass and do nothing if you're not lifting weights. That just turns you into a blob, a metabolically busted blob, which is what most of this country is. and that's not helping anything. So, no disrespect, but you know, most people are going from bed to the couch to their car to their desk, back to their car, back to their couch, back to their bed. It's no wonder why 94% of us adults are metabolically compromised. So, what should happen when

6: 01 compromised. So, what should happen when you lose weight? If you lose weight, especially fat and muscle, because anytime we caloric restrict, we're going to lose some muscle. Your body needs less fuel to operate. This is why it's really problematic when people lose weight. it's so difficult to keep it off and why the success rate of that is so low. It's because as you decrease your body size, you decrease your body mass. Your body needs less fuel to operate. So your resting metabolic rate is going to go down no matter what. No matter how you lose the weight, you are going to have some reduction in your resting metabolic rate. And that is going to cause problems in that now you have to eat less to maintain that size. This is the cycle and loop that folks with obesity get trapped in because they lose 100 pounds, let's say, or they lose 50 pounds or they lose 25 pounds and now their resting metabolic rate has gone down. So, it's going to take more exercise and less food to maintain what they just achieved. This is not an absolute true statement, but this is what I hear folks struggling with obesity say. It was almost easier before I lost the weight. At least I could maintain that set rate, right? And I didn't have to fight so hard to hold it. But once you lose weight, any of you who've lost any appreciable weight know to hold on to that weight loss, to hold on to where you've dropped to is really difficult to maintain. So the way that I explain this to folks is if you ran four miles a day to lose 5 lbs, once you've lost it, you have to now run five miles a day to maintain it or you have to eat much less. All right? So this is the expected resting metabolic rate drop.

7: 31 expected resting metabolic rate drop. This is what metabolic adaptation is. It's the body going into starvation mode and trying to desperately hold on to what it has because you've just taken away a bunch of mass if you've lost weight and your body is like, "Oh no, we must go into starvation mode." That's metabolic adaptation. We don't really want metabolic adaptation to go up. Meaning, the more that we have a metabolic adaptation, the more of a starvation mode we've gone into. Okay? So when you lose weight, there is an expected resting metabolic rate drop. But what sometimes actually happens, and they figured this out with a couple studies years back, most notably the Biggest Loser study. I'll go through that in a bit, the Biggest Loser study, and I'll explain what happened. But what sometimes happens is when you have a crash diet or you have a significant amount of weight loss in a short amount of time, you get an actual rate drop of your resting metabolic rate that is larger than expected. It's bigger than anticipated. This is what happens when people have a big drop in weight. That's metabolic adaptation, aka adaptive thermogenesis. It's your body going, "We're starving. Slow down everything and conserve energy." So, everything's going to slow down. Your thyroid function, everything's going to slow down. Your metabolic rate, everything's going to slow down because the body slamming the brakes saying, "We are starving. Do not lose any more weight." This is why I'm not a fan of losing weight quickly. This is why I tell you we don't want to lose more than one pound a week because we don't want to go

9: 01 pound a week because we don't want to go into a hyper response of metabolic adaptation. We expect a little bit, right? Because a leaner body needs less calories to run, but we don't want to slam the brakes here. So, think of your body as a furnace. Here's a scenario. You lose 30 lbs. All right. What should happen? Your furnace turns down to low. What actually happens is your furnace goes into hibernation mode because of this metabolic adaptation. Or say you lose 10 pounds, your furnace should drop by 150 calories a day. Instead, it drops to 300 calories a day, which is extra slowdown. That's metabolic adaptation. All right. So now, let's apply it to these studies. In caloric restriction, let's say you lose 10 to 15% of your body weight. You should see about 150 calorie a day resting metabolic rate drop. But what you actually see is a 250 to 300 calorie a day drop. Meaning it overcompensated. That's metabolic adaptation. This is this extra unwanted slowdown. Okay. In this study, interestingly, let's talk about the mice first. So the mice lost an appreciable amount of weight. They had their metabolic adaptation attenuated by the tzepide, meaning halted or lowered even. So they did not get the expected nor the hyper response of metabolic adaptation that one would expect when you lose an appreciable amount of weight. They had no metabolic slowdown. So everybody thought okay my

10: 30 slowdown. So everybody thought okay my studies tzepide must be really protective to metabolic health and there's no appreciable uh metabolic adaptation. So, yahoo. And they erroneously apply this to humans, which we do, you know, when we This is why I always try to clarify these are rodent studies or not because it doesn't always translate to humans. But what they found in this study in the humans when they looked at the 55 individuals that were split pretty evenly down the middle into two groups, they were on 15 milligrams of turppatite a week. That's a hefty dose. That's like the highest end of the entire dosing protocol. So, they were on the highest dose. They were try titrated up over like what I think 20 weeks and meaning they had their dosage doubled pretty quickly. They got up to 15 milligrams a week, very high dose, very very, you know, highest tier dose. And they lost 15% of their body weight, which is awesome, right? I mean, that's what they were going for. These were obese individuals. Their predicted resting metabolic rate drop would be, let's say, 150 calories. Their actual resting metabolic rate drop, what happened was they only decreased it by 150 calories a day. meaning their metabolic adaptation did not it it stalled in the middle. Meaning in people with obesity metabolic adaptation did not really happen. You know the rumor mill going around the internet right now is well that just means that they ate less calories therefore they lost weight and it's all about the calories in calories out kind of thing. And what I'm

12: 00 calories out kind of thing. And what I'm trying to express to you is that they had no metabolic adaptation which means they were protected. They should have had an appreciable drop in resting metabolic rate, but they did not. They had the expected drop. So, they did not have the hyper responsive metabolic drop off. They didn't go off the cliff like what happened in The Biggest Loser when people had a massive metabolic adaptation for years after they lost the weight. Years, you guys, people don't understand this. This goes on for years. If you're a largesized person and you lose an appreciable amount of weight, your success rate of keeping that weight off is abysmal. It's about as high of a success rate as rehab, which is also abysmal. We're talking five, maybe 10% chance of you keeping that weight off. That's what these folks are up against. So, when people say, "Oh, just eat less and move more." It is so shortsighted and ignorant because these folks are dealing with an uphill battle for the rest of their life. So, anyone you've seen lose an appreciable amount of weight and keep it off, like super kudos to them because that is not easy. It becomes literally harder than it was just to maintain the obese size is what I'm trying to get at here. If we lose 15% of our body weight, let's just say we go into caloric restriction. Let's just say we eat less and move more. We are going to not just have an expected drop in resting metabolic rate. If we do it quickly, we are going to have a profound drop in resting metabolic rate, which means we are going to have metabolic

13: 31 means we are going to have metabolic adaptation increase. With trizepetide, folks are protected from that. They just have the normal, hey, you are 15% smaller now and so we need less calories. But it's not exaggerated like it is in every other case like beriatric surgery or when people like on the Biggest Loser where they're put through horrific boot camp style training and starve to death. So eat less and move more is actually less successful in the long run than eating less and losing weight with trespective. That's what this study is showing. It's small. Again, it's a small study, but it certainly the way that I took it was not at all oh it was just the less calories they ate. I don't know if these docs actually read like paid for and read the whole study, but the other sure signal that this peptide these peptides are protective of metabolism and maybe even improving metabolic health overall, which I really believe. I really believe that they have a healing impact especially long term the longer people are on them on folks metabolic health overall. Is that fat oxidation increased? And the only way to lose weight is to have fat oxidation increase. So fat oxidation increasing on the peptide is a good sign that that metabolic health is being protected if not improved. And this was not a terribly long study. I think it was I want to say it was 9 months which is I mean a decent amount of time but most folks who are needing to lose significant weight I would really the

15: 00 significant weight I would really the way that I'm looking at it with my patients and with the folks that I'm working with or talking to even is we're seeing real improvements in metabolic health and the ability to titrate down around 16 to 18 months. It just depends on the individual. And so I know lots of people who were micro doing it who really didn't have much weight to lose. Again, micro doing is not a weight loss strategy. I don't even want to go on another rant about that because it is pissing me off. Um, I just had a gal send me a message or a someone else's story on Instagram and she's it's crazy you guys. I cannot rep for a tele medicine company and get paid a kickback or an affiliate kickback because that's called fee splitting in medicine. That's illegal. So that is why I have not aligned myself with any tele medicine companies whatsoever as far as financial is concerned. Influencers can I don't know how they're legally getting away with it but they can financially align themselves if they're not doctors they can align themselves with tele medicine companies spew out whatever the tele medicine company wants them to say have an affiliate link and get a kickback. So, all these influencers online trying to teach you about micro doing, they're all getting affiliate kickbacks or they're sending you to like the gray market, which is a pretty hard place to get these now, but you can buy this stuff online, right? And they're sending and God only knows what's in it because there is some counterfeit [__] going down. I just talked to one of my buddies, compounding pharmacist, and like I would stick to the brand name at

16: 30 like I would stick to the brand name at this point if you can because nobody knows even what's going into the compoundingies in some cases. It's getting pretty scary out there. So, I mean, unless your compounding pharmacy knows who they're sourcing from, there is some random [__] being circulated. Um, anyway, back to my point is these folks are getting a kickback. So, this gal is telling folks that micro doing is actually just the standard starting dose, which I've been really clear about. It's not. First of all, micro dosing is not a weight loss strategy. Second of all, it's not the standard starting dose. And third of all, it's a mere fraction. What that fraction is depends on the individual. It depends on a lot of factors that I go into deep on my GLP1 done university. That's why it's 40 hours of content plus because this is a nuance conversation. But that said, it's a fraction of the starting dose. So she's promoting the starting dose and her story literally says like this is micro doing and you know it's with simacle the starting dose is 0. 25 with trezepite it's 2. 5. And I literally wrote her back and corrected her. I said that's incorrect. This is wrong. This is not at all what micro dosing is. And she said well the tele medicine company that I rep for this is how they micro do. So this is what they want me to say. And this gets me back to my point that I've been trying to share with you guys. It's been co-opted. It's been rebranded. My words have been twisted. And these same people are using my name and sending people back to my podcast because Dr. Tina said it's all right. I never said that. I never said standard dose your

18: 01 that. I never said standard dose your patients and that's a micro dose and it's all right because I'm getting phone calls from other influencers who are supposedly being micro doing by big name influencer doctors and they call me and tell me they can't get off the couch because they can't stop vomiting. And I ask them what their dose is. And the same answer I get from people, oh I'm taking this many units. I'm like, I don't care what the units are. What is the strength of the bottle? So they send me a picture of their bottle. I do the math quickly. They're standard lowd dosing and they're being told they're micro doing and these doctors never bothered to have a conversation with me. These are the doctors that say, "Oh, I've been doing this forever." No, you haven't. This is not what I'm talking about. Micro doing work for weight loss for very long. It only works for those who are metabolically optimized already and they just have a little fluff to lose. But if you're actually going for weight loss, micro doing ain't going to get you there, honey. It will stop working. I've seen it time and time again because people keep thinking they can do it even though even the ones who are kind of listening to me and then they're like why did it stop working or why is it not working at all? I'm like because it's not a weight loss strategy or they're not doing all the things. All the things as you know which I lay out in the course in detail is all the things. It's the strength training. It's the hormones. I have a whole hormone module deep dive that will explain hormones to you better than anyone's explained hormones to you unless you've taken another awesome course somewhere. I promise you that module alone, the hormone module, is worth the price of the course. I've got expert interviews in there with almost a dozen different friends of mine, most of them licensed practitioners. So anyway, all that to

19: 30 practitioners. So anyway, all that to say, the way that folks are bastardizing my message across the internet is it's getting old, guys. That's all. I'll leave it at that. Okay, so let's get back to this. The expected resting metabolic rate drop would be a normal slowdown due to overall tissue loss, right? They're losing some muscle, they're losing some fat mass, their body should slow down their resting metabolic rate. Their actual resting metabolic rate, what you can is what you can measure. And metabolic adaptation is when the actual is more than what is expected. And in this case, Tzepide just gave them the actual amount. Let's get back to the summary here. The expected resting metabolic rate drop when people lose weight is due to normal tissue loss. Like you lose an amount of tissue, lean mass, fat mass. You're always going to lose some muscle. That's lean mass. That's part of lean mass I should say. You get an expected resting metabolic rate drop. The actual resting metabolic rate drop that happens with caloric restriction, unfortunately, that you can measure, it's what you measure, is usually always more than the expected. So in this case, the trezepite protected them and it just gave them the expected. There was not the falloff cliff. There was not a pronounced extra amount of resting metabolic rate drop. I hope that makes sense. I'm trying to explain physiology here. So it's metabolically protective. Um no unnecessary metabolic slowdown. The teptide users didn't

21: 01 slowdown. The teptide users didn't experience the bonus drop in their resting metabolic rate that sabotages most dieters. resting metabolic rate dropped only as expected, not extra. Based on fat and muscle loss, the bodies behaved predictably, not defensively. They didn't go into starvation mode. That's a win. Muscle mass, fat - free mass was reasonably preserved. How's this for you? About 75 to 80% of their weight loss was fat, which is better than diet induced losses. Most diet induced losses are anywhere between 25 and 40%. And I know we hear the stories, everybody loves to lean on that 40%. Because of one study that happened years ago. Oh, they lost 40% of their lean mass. Only a portion of lean mass loss is muscle. FYI, and some of it's the fatty infiltrate inside the muscle that they're not even accounting for. But some of these bigname health influencers and doctors really love to lean on that 40%. But when you get into the studies where they had people exercising or they had people take care to pay attention to their protein macros or even just gave them high doses of transepite and let them go like it looked like they did in this one, they actually had a significantly lower lean mass loss than we've seen in some of those other studies. So don't let people scare you on the internet. It's it's just it's [__] It's it is they're they are trying to scare you for some other reason. If someone's really trying to scare you about GLP1s, like first off, why do you care what anyone else is taking? It's so bewildering to me. And second off, they're trying to sell you their services or their supplements.

22: 30 their services or their supplements. Always. Just always go a layer deeper. They're always either selling services or supplements to you. So anyway, their fat oxidation increased. Their bodies became better at using fat for fuel. So they had a higher fat burn. That's a win. That's a metabolic win. And that tells me that Trzepatite is actually improving the metabolic terrain. Their appetite decreased without rebound. No compensatory spike in hunger hormones like ghrein. So I'm going to go with win here. It's protective. It's metabolic protection. It's not boosting metabolism like a stimulant or thyroid hormone. It's regulating the system so the body doesn't go into starvation mode and we don't have metabolic adaptation go rogue. Trisepide allows for weight loss without metabolic panic, if you will. That's what makes it powerful. It's very different from their just eating less calories that we're hearing on some of these reels on Instagram. So, I just wanted to share that. And lastly, let me leave you with the Biggest Loser study. This was the New England Journal of Medicine 2016. The summary was they followed contestants from the TV show who lost an average of 129 pounds over 30 weeks. That's crazy. That's a crazy amount of weight over 30 weeks. Do you guys remember watching that show? I remember watching it in horror. And I gotta say, anybody involved in that show that's still around today, I have no respect for because they did that to their people. They yelled at them. I remember certain influencers who are still online today yelling at the people. And these poor people are trying their best and their bodies are just I

24: 00 their best and their bodies are just I mean it's like tell me you know nothing about hormones and metabolic health. Like it's it's just wild. It was terrible to watch. These are people who are still with big platforms screaming that Ozmpic is evil. and I don't get it. So, they used extreme caloric restriction and intense exercise. For those of you who haven't seen The Biggest Loser, it was terrible. They basically put these people in a camp for 30 weeks and just pummeled them. What happened? Their resting metabolic rate dropped by 500 calories a day on average. This was a 275 calorie a day lower than predicted. This was severe, severe metabolic adaptation, as an example. Six years later, most had regained the weight and their resting metabolic rates were still suppressed. Which leads me to believe, I don't know if they followed them past that, but it leads me to believe that this might be forever. And I've heard this in the obesity community, and I've been studying obesity pretty intensely for the past two years, and I have a whole newfound appreciation for obesity as a disease. Go back and listen to the episode I just did with Dave Knap. He's the On the Pen guy. Um, that's his platform, On the Pen. really really nice guy, independent journalist. He lives with a disease of obesity and he talks about it quite a bit and I think he represents it well. But the bottom line was these folks on The Biggest Loser, their bodies were stuck in starvation mode, maybe forever permanently is what it looked like. That's what's happening to people who are losing massive calories or restricting massive calories in a short amount of time and losing massive amounts of weight. But the thing is is

25: 31 amounts of weight. But the thing is is this small study showed that Turszepatite is protective against that. I would say that's a massive win. It's significantly better than just saying, "Oh, they lost weight because they ate less." There was the calorie study, C A L E R I E study, long-term caloric restriction in non-obese humans. The summary was that participants restricted calories for 25% for two years. They lost moderate weight, 10 to 15% of their body weight. The metabolic effects, they also experienced metabolic adaptation. Their resting metabolic rate declined more than expected. They increased fatigue, cold sensitivity, hormonal suppression. Your thyroid just gets tanked out. In this case, sex hormones, your estrogen, your testosterone, progesterone, and elevated hunger. So, what these studies show us is that typical dieting causes the body to fight back. It pushes back. The bigger the calorie gap, the harder your metabolism hits the brakes, and weight loss is achieved at the cost of long-term metabolic health. So, all these folks out there, all these folks online saying it's just calories in, calories out. Eat less calories. Track your macros. Track your calories. I will say track your macros. Like if any I mean don't worry about any of them except eat enough protein is my stance on it. If you get enough protein and you're not going to have any room to be shoving in a bunch of terrible macros on top of it. But any of these folks helping everyone in the world with their caloric restriction. I really encourage them to track their clients and let me know how they're doing a year later or two years later or three years later because I've helped many patients with

27: 01 because I've helped many patients with caloric restriction and metabolic adaptation is real. Yo, and it is brutal and it's very hard for those folks to maintain that weight loss. And the argument against GLP1s that I've been hearing even recently on some big podcasts with some bigname doctors, I've been hearing them say, "Oh, well, the problem is is once you lose all the weight, your metabolic adaptation is going to kick in. It's going to be harder to keep it off." Yeah, except these peptides seem to be at leastide, which is a dual agonist, seems to be showing protection against that. So, sorry Dr. So and so who keeps spreading that information all over the world with his giant megaphone, you are not correct. All right, so if we were to break this down on a chart, this is how it would go. The Biggest Loser study, 30% weight loss, 500 calorie drop a day in their resting metabolic rate. Severe metabolic adaptation, high muscle loss, and very high long-term regain risk. All right, the calorie study again it's C A L E R I E like Valerie 10 to 15% loss of weight 10 to 15% more than predicted resting metabolic rate drop so moderate metabolic adaptation on that one moderate muscle loss and elevated long-term regain risk in this recent tzepide study from 2025 that I just

28: 30 tzepide study from 2025 that I just showed you 15% so more than In the calorie study, 15% weight loss. Their resting metabolic rate drop was only as predicted. So they did not have metabolic adaptation occur. None. Their muscle loss was lower. So their muscle was protected. Their fat oxidation was increased. So their metabolism was actually improving. And they had a lower risk of long-term regain. That's it. This stuff really is protecting metabolic health in my opinion. And I'm not saying there's any magic involved. I think it's very simple when you understand how metabolism works. You understand the like I said the insulin signaling, the insulin reception, the decrease in inflammation. Busted metabolic health is being driven by high inflammation. And that's why we call it inflammaging, right? As we age, you've heard me talk about that before. As we get older, we get more inflamed. And as we get more inflamed, we get more metabolically compromised. That's just how it goes. These peptides protect against that. That's huge. We get a decrease in inflammation in the brain. We have mountains of studies to show this at this point. We get microgal cell improvement in the brain. So when the brain calms down, a lot of what's happening downstream metabolically, imunologically, inflammation wise is being driven by what's happening centrally in the brain. It's not just central sensitization from a pain standpoint. It's happening across many parameters of an individual's health. GLP-1s dampen that inflammation down. So

30: 02 GLP-1s dampen that inflammation down. So really, anyone crapping on GLP1s at this point just sounds ignorant. And I keep hearing it from intelligent people. And I'm like, do y'all not keep up with any data because that ship has sailed. The crap on OPIC ship has sailed. It's over. It's embarrassing. I'm embarrassed for some of these people who keep crapping on these peptides. They just clearly don't get how they work and they clearly aren't listening. I mean, maybe they don't like me. That's cool, but I'm trying to lay down the actual data because misinformation, especially coming out of a camp that has a large megaphone. When you spew intentional misinformation, I don't know why these people continue to crap on OMIC, but I don't know who's paying them. Maybe it's because if GLP1's work as well as we know they do, it compromises their food first messaging. I don't know. But it negates all the rest of the scientific claims you make. If you in science, if you spew if you intentionally spew egregious misinformation, it negates your word across the rest of the science that you share. And so that's why it's really important to me that you guys understand the truth of this. Uh I'm not saying this is for everyone. I'm not saying everyone should take it. I'm not saying it's not not without risk, especially at 15 milligrams a week. I mean, that's a really high dose. But risk tolerance, right? And riskto benefit ratio. And

31: 30 right? And riskto benefit ratio. And that's a conversation for an individual and their doctor. That's not for me to decide. That is for a a conversation between an individual and their doctor. And it's nobody's business what an individual chooses to do about their health. We don't say boo when women put breast implants in. It's been so completely normalized. And I've been telling women from the beginning like don't do it. It's going to it potentially very much screw up your immune system. But yet it's been completely normalized. We don't say boo when people put filler or botox in their face. We don't say boo when people I mean shoot there's places you can go to get your bones extended. There's young men actually having their bones extended with terrible apparatus. They cut the femur and literally stretch their bones out and they make them taller. There's all kinds of things going on in the world that we don't say boo about. There's people who are my age who were on five different lifestyle medications for the rest of their life and no one says boo. They're on statins for life. They're on hormones for life. They're on I mean I'm on hormones, too. I can literally make an argument that every single one of the even the compounded hormones, the bio identical hormones. Yes, I'm going through menopause, but the fact that I needed some hormones in my 30s tells me that my lifestyle was burning my hormonal system out. So, I could make an argument for, you know, the 35year-olds who [__] on Ompic but take compounded thyroid. I'm like, honey, I could make an argument that your lifestyle is driving your thyroid to be worse, right? and that you might yeah maybe you do need some just you maybe you've always needed some but also

33: 00 maybe you've always needed some but also we drive our HPA axis into the ground through stress and through lifestyle we drive our cardioabolic health into the ground and we end up on statins and blood pressure medications and we don't say boo about that but god forbid somebody take a peptide that is going to literally protect their metabolic health if not start to heal it. It's crazy to me. Somewhere in 2021, people got awfully nosy about what other people were doing with their health. I'll leave it at that. And somehow that opened the Pandora's box to everybody seeming to think they have an opinion about what someone else chooses to do in their private life, with their private health decisions. But you guys can decide what you want to do because I'm going to keep giving you updated and truthful information, and you can decide what you want to do with it. I'm not going to go into a big rant about why I think the calories in calories out dogma is busted. I do see utility in the fact that if you want to lose weight, caloric restriction is very likely going to be part of that conversation, but it's not all of the conversation. And the easiest way I can explain this is we don't all have the same engines. So the amount of fuel you put into it is going to differ. We don't have the same we don't all have the same engines. And so it's not just less food. It's are these people insulin resistant? Do these people have hormonal imbalances? Do they need some hormones? Most notably. Um, yes, caloric restriction can potentially help you carry that, you know, that weight across the line. But I'll tell you this, every time I calorically restrict,

34: 32 this, every time I calorically restrict, and it's always by accident. I'm just naturally an undereater. Anytime I accidentally calorically restrict, I end up starting to gain belly fat. and I start losing muscle, I I go in the wrong direction. So, and the amount of patients I've seen, women, it's always women, who are severely calorically restricting and just crushing themselves in the gym. They're doing Orange Theory, they're doing CrossFit, they're so metabolically ramped up, and they just get fatter and fatter. And I have to tell them to stop. Slow the roll. Dial it back. Focus on nutrient-dense food and enough of it. Focus on hitting your protein macros. Stop worrying about everything else. Like I said, you won't have any room for anything else. Garbagey. And if you're going to the gym, trust me, if you're working your butt off trying to build muscle the smart way, there's a way to do this. I talk about it in my strength corner. You guys can grab that. I'll put the link in the show notes. It's a great course. It's a great beginner's course. It'll get you there. And then you will have an opportunity soon from there to join my uh strength and resilience collective. We've already gotten started. the people who joined the protein quest a few months ago or a month ago, uh they're in it. We're doing it together, but I'm going to open it up to the general public here soon. And there's a whole strength vault I'm building out in there. So, I'm going to keep giving you guys in there exercises, your programs for the month, your or workout programs. There'll be a whole library of exercise videos. You don't have to kill yourself. Three times a week strategic plenty.

36: 02 Three times a week strategic plenty. That's plenty. And you don't have to be a sweat angel on the floor when you're done. In fact, I'd prefer you're not because we don't want to drive cortisol so high that that high cortisol level will not allow your body to let go of the fat. So, this is where calories in, calories out fails. It fails in a lot of ways. I'm really glad it works for some people and I applaud the people trying to promote it online, but those who were militant about it clearly don't understand metabolic health and the nuances of it. They clearly don't understand hormones. They clearly don't Let's talk about leptin and light, right? I mean, you need light exposure and you need circadian rhythm balancing in order for your body to actually not go into metabolic illness. So, there's lots of factors here. There's toxicity. There's so many factors involved as to why a human's body may not want to give up fat. It may be holding it for various reasons. Some of it may be emotional. You know, maybe these people had a lot of adverse childhood events, have dealt with some abuse. A lot of women have dealt with severe abuse and end up packing on weight as a response to that seemingly out of nowhere. So, lots of reasons. There's people who were thrust into severe metabolic dysfunction, even type two diabetes, even type 1 diabetes after COVID because viruses, any virus can have a potential ill effect on different body systems. Maybe somebody's thyroid function is falling apart and you're telling them to calorically restrict, which is going to just crash out their thyroid function even further. It's bonkers to me. So, understanding

37: 32 It's bonkers to me. So, understanding physiology matters and understanding metabolic function matters. And I'm not again saying that I'm some expert in all of it. At the end of the day, I do understand metabolic adaptation and the impact it has on the body. And so eating less and moving more not the solution most of the time for most people where we're at now. That maybe worked in the 70s and 80s and 90s even when the world wasn't so toxic, but we're dealing with a whole different type of human here and a whole different type of metabolic compromise. And this is where I think GLP1's done right, done appropriately, can be magic. I talk about this in depth inside my program, GLP1 Done Right. If you guys want to hear the four-part video series that's completely free, I'll make sure the link is in the show notes. You just go to drtina. com / mpic uncovered. The program is now called GLP1's Uncovered. It is an excellent education on GLP1 agonist that you probably haven't heard. And from there, you will be given an invitation at a reduced rate for the opportunity to join the program. The program as it stands as of the time this podcast comes out is still intact. I'm pulling it down though because I have it was built out for clinicians. It's beefy and it's for the smart folks. If you're not a doc, if you're general pop, you know, we call them gen pop, the average humans out there in the world. Um, health coaches, strength and conditioning coaches, anybody dealing with clients who are on these peptides, I highly encourage you to purchase this course and go through it. It will teach you

39: 00 and go through it. It will teach you what you need to know. That said, I'm pulling it because I have allowed the general public in and what I want to do is create a certification program for prescribing clinicians and I'm really excited about that. That's what I'm working on lately. There will be a program available for um health coaches, non-licensed practitioners, chiropractors, acupuncturists, but it's going to be more money than what you see right now. And then from there for the general public, I'm going to have a much more dialed in, way less clinical, although some people really want that information. That's why I'm saying if you want that information, buy the course now because it's going away. But there will be a much more just action-packed how to like support your journey with GLP-1 type of program that's coming last. So if you are in any of those tiers of people, that encompasses everyone actually. You're either a prescribing doctor, you are a health professional that's non-licensed, or you don't have a prescribing license, or you're the general population, general public. I encourage you if you want the beefy version as it stands, the comprehensive OG version that I built out, gosh, a year ago, a little over a year ago, uh, grab the course as it stands. So, go to drtina. com / mpic uncovered. Watch the four-part video series. You'll get a new video each day. I believe the third day in, you'll get the invitation to purchase the course. I highly encourage you to do it. That's the best price you're going to get and it's going to go away soon, so it's not even going to be available. All right, much love, guys. Thank you. I hope this was helpful. Again, I will make sure to link this study for you, but you are only going to be able to read, I think, the first page

40: 31 be able to read, I think, the first page of it before it cuts you off and makes you pay for it. So, I've covered it here. You can buy it if you want and read it. But I think at the end of the day, what it's showing us is tepatite is very protective for your metabolism and your metabolic health and potentially if we're having fat oxidation increase, it's doing something well beyond just helping you reduce your calories more. I will bid you a do. Thanks for listening to the Dr. Tina Show. This is a Wellness Loud production produced by Drake Peterson and mixed by Mike Fry. Theme song is by John the Guilt. You can watch the full video version of this podcast inside the Spotify app or on YouTube. As always, you can email the podcast at podcasttina. com. That's drt na. And if you like this episode, please rate, review, and subscribe on your favorite podcast app. You can also find all of my offerings on my website at drtina. com. For more shows by my team, go to wellnessloud. com. See you next time and thanks for listening. This podcast is for generalformational purposes only. It does not constitute the practices of medicine, nursing, or other professional health care services, including the giving of medical advice. I am a doctor, but I am not your doctor. No doctor patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is intended not to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in

42: 01 should not disregard or delay in obtaining medical advice from any medical condition they have and they should seek the assistance of their health care professionals for any such conditions.