Mitochondria, Cold Exposure, and Cellular Resilience
Dr. Josh Axe on how cold exposure activates mitochondrial biogenesis, peptide therapy, and the cellular mechanisms behind hormetic stress adaptation.
Dr. Josh Axe on how cold exposure activates mitochondrial biogenesis, peptide therapy, and the cellular mechanisms behind hormetic stress adaptation.
The Bible to me is actually the greatest health book ever written. And it gets into so many details about toxicity and cleansing and healing. If something's been around for 5, 000 years, it's probably because it works. There are literally almost a 100, 000 people in Japan over 100 years old. Their form of medicine over there is a type of Chinese medicine which is called
passionate, driven human being. I know you know who this gentleman is. I'm really, really excited to have you back on the Ultimate Human podcast. Welcome, Dr. Axe. Gary, thanks for having me. Excited to be here. Yeah, me too, man. We've done challenges together and water fasting challenges and um you know we've done podcasts and we've done podcast swaps and I'm I'm
into so many details about regenerative farming, about if you have mold, what do you do about that? I want to go down and shelf and and all and toxicity and cleansing and healing. So there's a lot of amazing content in there. Uh, so that that's definitely become a, you know, continued to be a passion of mine is teaching people, hey, what does the Bible say in some of these traditional forms of medicine along with what does
medicine which is called compo combined with more of the functional medicine that we are aware of today. And that's a big reason why their lifespan is so long. So listen, if you want to live long, be healthy, heal disease, don't follow what a lot of the conventional medicine is doing in the United States. instead what are the people of Japan doing on a regular basis uh in order to stay well
all the dads who are spending time like soccer practice, full-time work, serving and play. I mean, really, so they we are so busy and this puts us in this sort of fight orflight state, right? I I remember going on a mission trip to China and it was a very similar thing in Japan to where there was there there was just a more of a cadence of rest and get refreshed. And I during lunch one day,
acids, it's it's all the things that drive our cellular biology. Yeah. And somehow we think that we can replace that absence with you know what what man makes us. Yeah. Um so you know back back to the the longevity I mean I know that you have a background as a chiropractor acupuncturist but and you are I would say very eastern philosophy in the way
what makes people well again at the very very top, even ahead of diet is this deep it's it's personal connection. It's your emotional health, your mental health, your spiritual health, your connection with God, your connection with others. I mean the Bible alludes this to and you know love God, love your neighbor and and then there are other areas where it says like like love the planet right so I think having these
and she said, "Listen, Josh, you'll never be a doctor with your GPA." She said, "Right now, you're getting a D minus in my class. I want you to stay after because you got an F on this paper." She goes, "You need to try harder. You'll be lucky to graduate high school." And and I Oh, it was I mean, it was she needs to read How to Win Friends and Influence People.
again barely getting through high school and then the teacher one teacher said something positive to me in that way and it radically changed my life. And everybody listening to this has probably had somebody do that. They've had somebody say something negative or somebody say something positive and it was a turning point in their life. And that that was true for me. And so now it was a little bit of a process
those things are. Okay, now that you've written those things down, I want you to do something. And this is hard for some depending upon the trauma. Write down how that has been used for good for life or you can use that for good that trauma and and I want you to see it in a totally different light where you're no longer the victim, you're the hero. You're now the hero of the story and God is going to be able to use this for good
aging do do I think they would all agree on? And I was like, um, I said likely the theory of immuno fatigue, which is a slow, progressive, overwhelming of the immune system. You know, if you look at when we're infants, the amount of time that the immune system spends policing ourselves versus protecting us from, you know, parasites, viruses, pathogens, glyphosate, BPAs, yeah, you know, PUFAS, all of these things. and and once we
autoimmune disease probably as the at the top of the list even things like cancer. You know what's fascinating to me is that as a category of of disease autoimmune in 85% of the cases is idiopathic. Um it's of unknown origin. So, you know, most people when they're told they have an autoimmune disease that it, you know, they're basically told you woke up one
from it. They'll say that is the biggest thing that taxes your immune system weakens your immune system. Um, German new medicine, if you're familiar with German new medicine, this is a German new medicine is really the psychological component that makes us sick or medicine. Yeah, it's a it's it's based off of, I think, a lot of the ideas of this kempo and Chinese medicine. But
to what you're saying that um it's not that it's has a sexual bias. It's that you know women for example are more likely to have caregiver syndrome. I know this from the mortality space. That's right. Um and and caregivers syndrome is a real syndrome where you just constantly put the needs of other people before your own. You know, your kids, your spouse, your career, uh what have you, and
Why is it so important? Um what how is it the genesis of or a driver of disease? How does it um help us be more resistant to disease and how could it be linked to to longevity? Yeah. You know what's interesting? A few years ago, oh, I shouldn't say a few years ago, my first two years in practice and you work this hard, too. So, it's uh like I was working 60 hours
uh zinc, vitamin D, magnesium, these are critical. But then there's this idea of cellular energy and in kempo Chinese medicine Ayurveda they would call thisqi this is your energy and that's really tied that's what mitochondria is today and this this ATP this cellular energy and so in order to boost that the most if we're looking at modern science and then ancient science so modern science they would say uh there's this compound
sense of purpose and taking action on that, you know. And I put this in a recent book that only 25% of people know what their purpose is. Wow. And so 75% of people are kind of wondering, not feeling like really in tune with what their calling is in life. And that leads to lack of motivation. That's going to affect things. But again, finding your purpose and living
Did they die of, you know, multi systemm organ failure, this autoimmune condition, you know, and we and it was was that prediction correct? And I was very desensitized to that. And when I had this spiritual epiphany and and decided I wanted to move into helping people live healthier lives and happier lives, longer lives. I mean, for me, I've that was a massive spiritual re revolution. I shed the old Gary and I
the fourth, and this isn't always included, but sometimes uh they would include what can you uh make a living doing? what can what what can you you know uh what can be tied to that monetize it. Yeah. And so and that's sometimes included not always within that that exercise. And I'll say this as well. Here's another example of of I think what gives me a sense of purpose. So um I know we were talking about this
dad um I had such a good dad. My dad like provided for our family. He was like a great disciplinarian. Like my dad never missed I I played over a thousand, you know, I played basketball and soccer and whatever. I mean thousands of games. And my I never remember my dad missing a single one. That's not And so that's a blessing, man. That is a true blessing. It
of somebody's eternity. And so, I think the more that we can tap into these spiritual truths because today like and I'm seeing this growing more and more like people want to hear about this message, they want to people are seeking out faith more than ever before. But I think we went through this period of time where the world was very cold and we kind of took spirituality out of everything and the
entertainment. It's actually not connection. It's distraction. That's right. you know, there's there's no element of humanity there. Um, and I think that that's, you know, one of the underlying root causes of these parabolic rises in autoimmune and the state of chronic disease. But before we get lost in that, um, yeah, I I did want to say when it comes to mitochondrial health though, so so
aren't doing it near enough because the other thing is when you're getting the sun, you're not only getting red light, you're getting blue and green and violet. like you're getting all these other forms of light that actually have differing benefits. Where red light be might be more active towards mitochondria, blue light is actually highly anti-inflammatory. So there are some different types of light you're
to be to bring gases to the lung, not bleed fluid into the lung and bring gases back, you know, to tissues. I mean, this is very small vascule. Yeah. Red light really caters to that 70% of the circulatory system. can actually restore uh vascular laxity to these, you know, can restore vasa motor and v vasa motion activity. So yeah, I'm just a
your labs. Um the effects of it may or may not. Yeah. um unless you're doing very specific labs, but I'm saying on a routine blood panel, hormones, uh you know, thyroid, you know, your lipid panel, CBC, CMP, you're not going to catch these things. And what I see in the community that I have a VIP community where I'm very interactive with and I would say as a broad
"I feel awful, but my blood work is normal." Yeah. And then doctors thousands. Yeah. And doctors will say oftentimes, it's all in your head. You're fine. Here's the thing about a lot of lab work, though. It might look at what's in your blood, but it doesn't look at what's going on inside your cell. It
but that's not happening. And so the first thing people need to do if they have a parasitic infection or any infection, lime, longco, they need to strengthen their immune system, get more rest, spend more time in the sun, uh spend more time with community, um and then take herbals and eat foods that are immune strengthening. Not the ones that are killing things, but that are strengthening your own immune
he was diagnosed about a year ago with glyobblasto and glyobblasto well you know this from the I mean your chance of living is one is less than 1%% right over five years it's like it's almost it's like one in 10, 000 I mean it's it's so low he's a year now going strong just readed his scans markers are perfect feels
that, you often times want to do binders. Now, a lot of people like activated charcoal. I I'm not as big a fan of that. I'm, you know, short term, I think it's great. Like, if I have somebody having the servo fillings removed or a twoe cleanse, I'll have them do that and I think it's fantastic. But I think if you're going to do something a little more longterm, I really like clay. I really like
a parabolic rise. Um, there's it was crazy this year, the amount of ticks. Crazy. Yeah. Um, I mean, I have quite a few clients that are going through through lime protocols with me. But, you know, the interesting thing about lime is it's not usually just the viral infection. You have co-infections. you know, the the parasitic infection and the
with like the joint pain and some of the things you'd see of of lime. A lot of people have lime but if you're immune system strong enough you you will have no symptoms. So my point there is is that you do need to take something to help kill lime, but more importantly, you need to strengthen your own system so your im your own immune system can keep lime and cancer and all the other co - infections at bay. There's another
knotweed that's really high in rveratrol. Um and then you've got cat's claws popular andrographus would be another one. Um but but yeah I mean and those are probably some of the best and then but that's what I would do and then take your time you know and do a lot of the other biohacking things you talked about. I really think deep breathing and
on like I took a limitless pill. I was eating my wife's face and she's like, "I didn't sleep on the plane. You need to shut up." I mean, like, I'm so happy to be here. Look at the ocean. There's a palm trees. Look how tall that building is. I was just like capped and chatty. I was just on fire. I felt amazing the next day. Um, the second time I did it, I felt a little fatigued for for two full
what does the medical literature say? What does the ancient medicine say and combine those two and take the greatest sort of ideas from from those. But but peptide therapy, if you want to go back to the original peptide therapy, it was taking glandulars and organs. I mean, that's where they're f found in the highest levels in the body. And so thyosin alpha 1 like before you had thy thyosin or
was after taking BPC-157, TB500, and the GHKCU, that blend." I I could not believe the pain reduction, the the my mobility improve. And so I'm a big fan. I will say there there's this sort of old quote and it's the dose determines the medicine or the poison. So the dosage I think is important for certain peptides. This is where the GLP1 like the an example. The micro dosing I guess I don't really have much of a
heals the liver, cardiolipin heals the heart. So it's so these are organ derived peptides to support bad organs function which is you know BPC is a gastric pentideca peptide. It's just like that and I think you know we we've used it to heal and seal the gut. Um I take the peptide patches. I have this nagging uh bicep tendon tear that I've just been
recognizes, we have enzymes for, we have waste elimination pathways for. So, you know, you eat a piece of chicken, the chicken gets broken down, that protein gets broken down to the amino acids. The amino acids essentially become other tissues or build other proteins. But it but and then whatever that waste is from that methylation process the body can get rid of. So we can metabolize them and then get rid of the waste. And then
Oh, very long time. Oh, yeah. You know, when I started going through with sort of this microscope and lens of what does the Bible say about health, healing, and longevity, you'll start to see it everywhere. I mean, absolut everywhere from Genesis to the book of Revelation. Here's an example. You know, uh, Genesis, when you're reading it and actually
feeders like pork and shellfish and you know, and and a lot of these certain other types of animals, bats, uh reptiles, you don't eat those because they store toxins." Ah, and they don't eliminate very well. So, when you're eating, that's the issue with pork today, by the you know, I get some push back on this one because
also, you know, Stephen Ferdick. There's a lot of these pastors, they're actually much more into health, I think, than the previous generation. But all that being said, I think the biblio diet first and foremost is focusing on honoring God with your body and following the advice in the Bible. So it's staying away from pork and shfish. You know, the most commonly referenced foods in the Bible
medications and chemicals in it. One of them that was very high in was estradiol which is going to cause you know a lot of these young girls are hitting menration so early. You know a lot of men are testosterone levels low and it's in part due to all these hormones and our milk and meat supply. But but you know, ancient dairy was super high in probiotics, minerals, fat, soluble vitamins, and um and then honey was used
shooting and um and uh there there was some really uh well-known people and even a pastor saying, "We need to pray for this person's family for this." And then somebody said, you know, prayer doesn't do anything. It's not enough. I saw that unfolding. Yeah. Heartbreaking. And you know what? Um especially when the people that the
uh these are the community. This is the community that I'm I'm building. So, uh and every time I I have a podcast, we you know, we end the podcast and we go into a private room and they get to ask you questions directly and there's a whole bunch of questions for you. So, yeah, let's do it. If you're interested in becoming a VIP, you can head over to the
podcast. If you're interested in becoming a VIP, just head over to the ultimatehum. comvip. And until next time, that's just science.
Transcript auto-generated by YouTube. Verbatim — duplicates intentionally preserved.
the science of cold exposure triggers mitochondrial biogenesis through controlled cellular stress
Peptide therapy can enhance recovery and metabolic function when combined with environmental stressors
Parasite infections impair mitochondrial function—addressing gut health amplifies cold therapy benefits
Hormesis operates at the cellular level: stress signals activate protective pathways
"The body adapts to what you consistently demand of it—controlled stress builds resilience when applied deliberately."