Injury Peptides and the Promise of Repair: Full Transcript

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0: 02 well in my neighborhood uh all my neighbors ring my doorbell and they have some type of injury so they they just point to where they need a peptide injected so they point to their shoulder or to the Elbow their foot their ankle so I have every day someone's bringing my doorbell to get a peptide sh so uh Edwin it's great to be here with you we're at the Integrative Healthcare Symposium live and we're recording this podcast about a topic that I think is sort of captured a lot of people's imagination particularly longevity biohacking space which is peptides and and I don't know if the average person even knows what a peptide is but we're gonna get into what they are but they're highly prevalent in the body they're things your body makes to regulate almost everything that's going on they're little mini mini proteins essentially that um are the communication network of your body and they regulate every single function from your hormones to your brain function to your immune system your sexual function to tissue repair I mean it it it's quite amazing that that we've kind of you know gone this long in medicine without really taking a hard look at peptides in a in in a conventional way now there are things that people know of as peptides that you don't even know are peptides right like insulin is a peptide exactly OIC is now the Blockbuster drug of the dayde yes and that's a pep that's a peptide soe is a peptide yeah so there's a lot of compounds that we use in medicine that are peptides

1: 30 that are peptides uh there's probably over 7, 000 produced by the body right um actually technically 300, 000 okay I was up by a few thousand but we only understand a fraction of it and uh outside of nature uh there's uh I think a estimate about six million peptides out there that's incredible six million I mean a lot from Venoms and from animals and in my my book not in human pepti but other P oh yeah Dairy and there really amazing uh spiders and just interesting creatures Nature has a lot of wealth of now as a functional medicine doctor uh and reg medicine you know interest inen medicine I I really love the idea of using bioidentical molecules to support the body to do what it's supposed to do yeah so there's drug is essentially a new to Nature molecule that interferes or interrupts or blocks some path between the body and there's usually Downstream side effects um peptides also can have side effects when us pharmacological doses like we're seeing with those emping but these are biomolecules that have we've evolved over you know Millennia that regulate everything that's happening in our body so uh they're they're getting a lot of kind of play in the longevity space to optimize cognitive Health to rejuvenate your skin to help with tissue repair to improve sexuality Vitality longevity um so kind of take us from the top down what are peptides how do they work in the body and how can they be used to treat disease

3: 00 used to treat disease optimiz health and rejuvenate our biology you did a great um explanation of peptides but um the way I explained to my patients Mark is that uh peptides are singly molecules they're miniature proteins small little proteins they're made of amino acids and um unfortunately the FDA has just arbitrary just made a clarification that under 40 amino acids um is consider a peptide over 40 is a biologic and then over 100 Mino acids traditionally has been consider a protein yeah so it's the length of basically how many amino acids are put together um and like I said there's U the body makes uh 300, 000 peptides we only understand a fraction of it and uh anyway it's uh it's really fun to to read the research that's out there um and uh I I just I explained that um peptide speak to my patient is a signaling molecule it's short acting and it's like a doorbell ringing um someone ringing your doorbell that's a peptide and some a reaction is going to happen either your dog's going to bark or someone's going to answer the door um so if you give a peptide to basically help your immune system like thin alpha 1 um that's going to stimulate your immune system work better so that's a natural peptide produced by your thymus gland and as you know Mark you know it's it's thyroid and thymus it's always patients always get confused but it sits like in your chest and um between between your lungs in front of your heart and I have

4: 31 lungs in front of your heart and I have some sweet breads if you like V sweet breads it's it's when you go to the restaurant you chanc your restaurant they great sweet breads that's what it is it's your thus CL I didn't know that you didn't know that interesting I should order some sweep R so um I wonder if eating it is actually good I mean if you get any ta1 or peptides from eating it after it's cooked I don't know well they did a study you probably read uh that basically they gave human growth hormone and that form in DHEA and it it improved their thy the thymus improved it was only a men so they're going to do another trial um curious if it's women but uh anyway if the thus uh gets healthier your immune system gets healthier so that's one key component yeah have a healthy immune system so how do they actually work are they like binding to receptors and activating gene expression and regulating various kind of protein networks in the body some peptides are so small like epithin it can actually slip through and go through the nucleus and interact with the DNA through the hstone uh binding sites ah and it's some of these peptides were discovered by Dr cson Who uh from St Petersburg Russia he's has probably like 40 years of research of these wonderful peptides and unfortunately he just passed away um a couple uh weeks ago so I'm really sad about that um I have so many questions to ask and you didn't get to ask and I did have a privilege to talk to him once but uh anyway to me he's like one of the top s scientist um

6: 00 he's like one of the top s scientist um and he should have got the Noel prize in medicine um yeah it's quite amazing but but it also acts in certain receptors so um there there's a group of receptor called the G protein couple receptor uh and most peptides interact with that um receptor um and basically caus a Cascade Event uh and then basically um it's like doorbell ringing and then you get a cascet event well it's like insulin insulin binds to a receptor's yes cell and then kind of opens the gate for the glucose to go in the cell and pp1 agonists do a similar thing like oeg there's a receptor yes so um exactly so it's a general class called the G protein couple receptors there it won the Nobel Prize in medicine the G protein couple yeah yeah incredible so so they they're um about 150 peptides now out of the 300, 000 said uh that are are being researched for medical applications right and and there's over 80 peptides that are already approved by the FDA right right for medical use um what the kinds of things that people should be aware of that peptides work well for or maybe even better than traditional um therapies well in my neighborhood uh all my neighbors ring my doorbell and they have some type of injury so they they just point to where they need a peptide injected so they point to their shoulder or to the Elbow their foot the ankle so I have every day someone's bringing my doorbell to a peptide shot but I usually give bpc 157

7: 33 peptide shot but I usually give bpc 157 um which is one of my favorite peptides uh it comes from her stomach stomach fluid and uh actually the history is kind of interesting about that peptide it's um I really uh anyway I can go into that but it was recently discovered like in 1990s in Croatia yeah uh and uh anyway I I actually published the first human clinical trial in pep a lot of uh research in animals but uh I'm conducting two more human clinical trials and which is really exciting that's amazing so bb57 for example is a peptide that U the body produces uh is it I'm assuming it's made synthetically in the lab by putting together the sequence of it they sequence the amino acids and and they put together that stringing Mass so it's it's but it's a bioidentical molecu right so like making testosterone in the lab or making various molecules and and uh and then bb57 let's just sort of unpack that because that's a very popular one I personally used it I've had a bicep tendonitis I was you know doing some uh strength training and kind of irritated and I'm like well I'm just going to shoot some bp157 in there I did a couple of shots and it went away Fant and it was impressive um and I've used it for other things as well and found them really very effective uh for immune function you know when I have I had Co I for

9: 02 you know when I have I had Co I for example used ta1 as a peptide use it in my patients um BB 1. 7 let's sort of just unpack that for a minute how does that work in the body when you inject it for example systemically and your I mean subcutaneous fat your abdomen or if you have an issue with a particular muscle uh tendon when you a tendon tear you inject it into that what's actually happening is it well for tendon tear muscle tear or even um like I inject in patient joints um and they have a tear what what it's interesting is that U um the one classic study that was done is they had these rats and they cut the killes that sounds fun so poor rats uh and and basically one group basically got bpc injected in their stomach and other group just got Placebo and the group that gaed in injected into their stomach and a month later they were walking again and you don't see that in nature when you have an ailles doesn't K by itself exactly this was the first thing that was shown and that was like w wow so for my son he had um basically he was in high school was a cross country team he had like sixpack he just like Born to Run uh he he's developed a basically ITB injury ille toal band and he couldn't even walk we call it right yeah so he just could not even get in and out of the car and I told him he was in ninth grade I said son I can inject

10: 32 in ninth grade I said son I can inject bpc into your um you know into your leg and he said you aren't F in doing that so I had to show slides and I show him the rat I had to show him hard data yeah and he goes okay you can eject and then literally you know he's he was I don't know 15 at that time he quickly recovered uh and like a week later he was running again that's amazing it's amazing and so it actually helps uh there's multiple uh iies on how it it could help but number one it reduces inflammation it recruits your immune system to basically heal but the one part is there's a receptor called the um fatline C receptor that uh activates your growth hormone receptor so it's a pathway to help growth hormone receptors uh to be activated so that whatever growth hormone you have you can actually uh heal faster so growth hormone is really involved in healing and repair exactly it's an an it's an anabolic hormone but you need the receptions and that's what uh bpc157 does and there was a study that once they stopped it 3 days later they still had high expression of receptor so if you use growth hormone peptides with basically uh bpc and tb4 you will heal much faster so I have people all I have so many patients who had all these massive injes test some Orin peptides you mean for adding yeah CJC 1295 Tesa Morland yes they can all help heal faster too amazing so it works by helping for

12: 00 amazing so it works by helping for example growth hormone there may be mechanisms actually we don't really understand yet uh what you said in the rat was interesting is they just injected into the abdominal fat right it's a singly molecule so it basically tells the body to but but you didn't have to inject into Achilles they they did not inject even near the does it work better if you inject it near the sight as yes it always does work better but that study was like truly like mindblowing in the belly the rat and the kill F it's quite amazing and and you know in you know some ways uh peptides are used to treat um you know injury or illness right like for example bp157 or insulin OIC you could say would be something that would be a semaglutide peptide that would be used to treat obesity or diabetes or to help with various things that it helps with but but many of the peptides are are not really treating disease so much as as bioregulators that uh regulate our bodily functions to optimize them right right and my favorite one in regards to bioregulators is epithin yeah e p i t h a l o n and that was discovered by Dr cson and so for example four amino acid pepti four amino acids seem like what would it do comes naturally from our pineal gland and as we get older like our thymus gland it will calcify and will Shel up and you lose melatonin and you lose epithin from the pineal gland ah and when you lose epithin what happens is your cells that supposed to

13: 31 your cells that supposed to self-replicate get stuck in G2 so there's there self-replication so if you want a new skin cell your body basically can get rid of the old C skin cell and then you generate new skin cells inside our body we can generate new heart cells new myocytes new liver cells new panc our ability gets less exactly because we're losing epipal and epithin basically turns on cell cycle it's the peptide to make you younger and I have p s who have a pre-diabetes or a type 2 diabetes some of them have reduction of their medication or even get off their insulin I have patients who basically their macular degeneration is improving their vision is getting better so it's actually making you younger but you can't self-replicate forever because then you have discovered immortality which I haven't discovered yet but anyway far for me I don't think I'll ever do it but I'll ever find it but anyway I have patience say hurry up Dr Lee time but Epal is Just Amazing Just I just love it I mean it's is this something you take every day is it something you take cavison wants you to cycle it and so I have made my patients uh which is sad because the FDA has this on the chopping blocks there too uh in terms of banning peptides but um you can get epitalon spray which is actually nasal spray no under the tongue normally you have to inject the is that there's so many on the on

15: 00 the is that there's so many on the internet but if you can get from Russia the original one Cav sure there's not a lot of Commerce Going Back in Forth with Russia China through China yeah yeah got the black market for Pep well this one's a spray and this one I trust Dr caverson yeah so you know these are I don't trust the other ones I it's cavon brand so so you mentioned for example sort of ethalon as a b regulator that controls or self replication healing repair um and so they're not like treating a disease right exactly so you get it so what happens is insulin can treat type 1 diabetes and that's great but not all peptides are doing that in fact most of them are not they're they're actually simply just enhancing function like uh yeah like pt41 for example we both both at the same peptide same time yeah that's a yes for better libido better sex drive for women sex appr for and and it also works for men yes um I have a lot of men and women on it so it increases desire so does oxytocin oxytocin is actually FD approved is a peptide it's FD approved yeah so oxytocin is the love molecule when you after sex or when you there's a lot of uh other benefits and my nurse practitioner Becky Murray uh is going to do a webinar um I host a monthly webinar not as popular as yours I you probably have thousands I have only 30 people

16: 31 thousands I have only 30 people following but anyway one day I'll be as popular as you mark well let's see let's good no there's no way I mean you're like New York Times best seller that's all right well no one bought my books I bought your book actually you know what I went on Kindle and it was free because I think it's part of the Kindle unlimited oh really yeah I'm going to take it off Amazon I was going to buy it I was like Wow Kindle unlimited this is great this is I get no maybe 10 cents a year from Amazon so let's kind of dive in a little deeper around around some of the use cases um and and where are you finding you know the top value for peptides in clinical practice and for patients uh what what are the ones you like to use what are they Ed for well okay number one that I just truly love is if you want skin ghk copper Dr picker discovered ghk and it's a natural uh byproduct so when you have collagen and basically breaks down part of it is ghk so ghk can turn on your fiberblast to make more basically coll and hyaluronic acid and make your skin look better yeah um and you don't have to inject it in your face you can just put in your abdomen well we have ghk copper topical topical yeah so I'm not that smart not that good-look I'm not not a great athlete but I have good skin even though I don't I live in Florida and I don't even use any sunscreen but I use tons of ghk copper on your face oh

18: 01 use tons of ghk copper on your face oh yeah too I love it yeah and I tell all my stins like hell when you inject it well no no I'm talking about topical but you can inject and for my father who has uh who passed away recently with a very aggressive cancer t soloma a small bow um he had a great life and he he basically uh was told you really have like 30 days to live uh chemo radiation won't work and I said all right dad you're in like basically uh in a walker let me give you some peptides and so I mean for cancer I mean there's several different Pepes that has a lot of uh clinical studies in so alyus Alpha One um can help uh to help your immune system fight cancer oh yeah as an adant so not cure not a cure we're not saying it's a cure what you're saying it's oh yeah yeah all all the studies even stage for uh most of them shows basically Improvement of um basically longevity there of mortality uh so thymus alpha 1 has been used you can use U basically met and keflin um which I was using GK copper turns off um also U cancer genes uh epithin can also do that so um I told my dad um you're going to get uh some peptides and I already drew it up and my dad goes I don't want them he's like C St it he goes I don't want to live he goes I said it's too late dad mom is going to inject you anyway so

19: 30 you anyway so you can say whatever you want and we got eight great months with my that's amazing that's aming so he went from like literally from a walker to walking two miles a day regained his weight and incredible yeah all through peptides yeah and better nutrition too yeah amazing so um you know so kind of going down again into the sort of the rabbit hole of like what are the best use cases what are the top peptides in your toolkit right um for example I know like my best supplements are magnesium vitamin fish oil like those are my go-to right probiotic what are the in your I would say um number one is u i I love bpc157 um you can take it orally um people with reflux it tightens the Lees Junction I have some people get off their reflux medicine that's the bottom of your esophagus where where the kind of reflux happens come back up from the stomach and there's not many things that tighten Lees Junction yeah that's a lower esophageal sphincter like a sphincter at the bottom of your sagus and that that's loose and you get as it comes up you get reflex gir and all that it's impressive uh but bpc has uh FYI just I have people taking it and you know I inject peptides in their elbow and a month later they reinjure their elbow but they go I've been taking that bpc my my shoulder I can sleep much better so it's it's um it can improve your entire body so I call the Wolverine peptide um so you'll get younger the so you can grow back yeah so you can say Wolverine peptide that's great some

21: 00 that's great some people7 that's a top of your list so we talked a bit about that and it's great for injuries for trauma for tissue repair um and and you know I think it's it's one of the ones that I tend to rely on because I think it it really personally it's helped me and I think it helps a lot of patients what what other um and there what other peptides I love thus in alpha one because as we get older our thymus gland shrivels up and we're trying to basically help the thymus gland I mean your immune system get healthier and you know Mark you know you got to have a healthy immune system because once it goes down it goes to two ways it goes to cancer or to infection so we got immunosenescence which means the Aging of our immune system which is why when you're older you get more infections you can't fight them as well you die of pneumonia you don't respond as well as the vaccines and uh you get you know looking at covid the people who are elderly have the higher risk of death and so I think you're you're talking about a very important phenomena that we don't really have a good treatment for with traditional medicine so generally I tell my patients to use like uh 250 micrograms um of uh thus onha one like once or twice a week just as as just not daily you can use daily if you're sick like higher doses like if yeah my wife one day she goes she when she gets sick it's like it's a nightmare because I don't know when when to drop the kids off do I give them lunch money do I I where do I pick them up you don't have the playbook for I just Uber driver so yeah I don't I mean so one of my kid kids were younger um my

22: 30 so one of my kid kids were younger um my wife goes I took everything the C the D the zinc you know silver I'm coming down with something and I said she goes you have something else and I go yeah yeah in the fridge I have the thus alha one so I gave her I remember this clue it was way before Co probably I mean 2016 or something like that so I gave her about one one milligram of thus Alpha One next morning she was perfect it's like thank God cuz if she was sick I wouldn't know how to handle the kid I me we don't have the cure for the common cold but if you take this if you start to feel sick you when you get that feeling I think I'm getting sick and you take it it can be profoundly effective oh exactly exactly yeah what what else besides T1 and bp157 uh I love epith thalon uh then generally we do five milligrams uh subq daily for like 10 days if you skip a day or like the weekend you forget that's okay just just make sure you finish the V so One V will have 550 milligrams of uh Epal twice a year so you do it twice a year yeah so like 10 days twice a year it's kind of a reset for your longevity um and I have people like for me when I was doing it it's amazing my sleep I was on melatonin every year higher and higher higher Doses and do you know Epal turns on three genes of your pineal gland to make melatonin and my wife goes how come you're not taking melatonin anymore I like I don't need it I could sleep without it so it can reset your pineal line and help you to sleep better so I love thatal because as we get

24: 00 love thatal because as we get older and you mentioned the the Russian version bya the nasal spray but you can also take it not nasal it's under the tongue under the tong but you can also do it through injection through a 503a compound pharmacy prescription yeah amazing and and the the um the problem is that most people when they hear this they're going to get addicted to Epal do not use it every day for the rest of your life because you're going to stop the Magic in terms of self application it will eventually like the hay flick uh theory is just it's going to stuff in terms of it's no longer going to work just because a little bit's good doesn't mean A lot's better exactly so yeah just be patient and don't don't take it every day of the year because it's going to eventually stop working now now you know the other thing that sort of happens as we get older is is um we end up with with uh hormonal changes uh you know lower testosterone we have you know lower growth hormone we tend to lose muscle we we sort of age as a result of Chang in our hormonal environment um and what was interesting a lot of these peptides can be involved in regulating hormone function and well yes there there are um like regards to women that are done with they in postmenopause or finished with mental cycle sometimes I tell them like you may start your period coming back and if you get pregnant please mention me because I want to be famous nation in chire because I can't be famous like you so I have to go the other rout uh so anyway um yeah it's amazing they

25: 31 uh so anyway um yeah it's amazing they go my period was gone five years ago and I was coming back so I don't know how long it's going to keep on going but they've in the animal studies using which peptide epithin epithin yeah interesting so Varian function gets better so it works not just on the pineal gland but also May the hypothalamus can help the heart there there's because it turns on gene expression uh that which is interesting certain proteins that get kicked off and things work so epithin is like to me that's a good one I love it people are using other ones like kisspeptin which is for testosterone yes kis peptin 10 it's uh may work like canell and to help with testosterone function but uh um yeah those are peptides um that may or may not work in men it's it's confusing because the data was IV and they would do it like 24 hours and per body weight and it's hard to convert that to how do you do it sub Q so um anyway I have some some guys uh with some better testosterone level with using ceptin then there's the whole growth hormone um category of of supportive peptides like Tessa Morin right uh samorin CJC right uh Phil 95 can you talk about those and and what role they have and what they do yeah there's um really interesting in terms of growth homon peptides um so um I just want to

27: 03 homon peptides um so um I just want to start off with out of all the side effects of all the peptides that class has the most common side effects interesting so it may affect about 20% of patients and they can't take it anymore they really get welts in their injection sites uh and then some people really get really bad rashes and it's its entire body so um I I warn them that you know if you see the wel just growing to stop you're developing antibodies to it and you're you're not going to be even if you stop and retake it like like 6 months later it's going to happen again so your body doesn't like it now everyone I have some people on for five six years and no reactions and doing well uh so they're all very slightly they're very similar but they there's two receptors in the pituitary gland there's a gin receptor and then there's basically the growth hormone uh receptor uh so these peptides can interact to either one and uh like you would do CJC with 1295 uh which which is part of the growth Homa it's like part of the active part of the growth Homa uh that activates the pituitary um um gland at the growth hormone receptor and then iperm Moran basically interacts with the grin receptor so in combination you have a higher level of basically of growth hormone release um and one of the conse qu of having that higher level of growth homone release well this is the

28: 32 homone release well this is the controversy about growth homo does growth homo make you younger or older and the literature is all over the place I am doing a study on that uh which is um because I could show you literature on both sides of the but generally growth hormones considered the found of Youth uh but if you overuse it I think it's bad it'ser I agree so I think in little use and not bodybuilding use I think they'll do fine so so these these compounds you know you sort of hinted at a little bit but you know they they are powerful biomolecules like OIC for example or semaglutide we're finding that you know in the doses that it's being given for weight loss and for diabetes at two years plus we're seeing significant side effects like increasing bow wall thickness small bowel obstruction pancreatitis and other things and and so these are not completely risk-free compounds so how do you navigate issue around safety um you think oh they're natural compounds it's safe I can take them and people are playing with them yeah so with use of semaglutide or OIC or mjo or trapti which is and there are others um that's uh Zab just got FDA approval for U it's trapti for weight loss there so just but the thing is that um I'm was kind of the kid of the glp1 way before the movie

30: 00 kid of the glp1 way before the movie starts I wish I got the hashtag skinny pen but anyway I don't even do social media so I don't even you know I'm not on Facebook so are you recommending semaglutide to your patients before or was I think was s of a big deal refuse I have patients basically you you're stuck they go I just need a little help and then we work on lifestyle modification I want you to basically like really work on physical activity you know get your steps in try to get your high in interval let's clean up the diet and maybe use it sparingly I I'm okay with that like you maybe 3 months a year like during the holidays they know that you know Thanksgiving Christmas too much Temptations and then after that you know they go okay I'm fine so yeah if you can taper off or maybe use it sparingly I think it's perfectly fine there is a product that's called a cow curb it's a natural herb which actually activates um basically the bitter receptor in the um small Tesla and it releases your natural gp1 and cck to inhibit appetite so I have some of my patients I go let's see if you can use this uh and get off your yeah I mean there's a whole set of ways of naturally to raise gp1 right uh whether it's certain compounds for example himine Ty Buck works and the lower um intestin with these taste receptors to increase ch1 um various kinds of polyphenols and other things can help so it's definit it's not just the drug that can do it um but you

31: 31 just the drug that can do it um but you but there are you know concerns around side effects if you tend to use these things properly if you don't have proper guidance if you don't understand the risks um you can you know get anybody as you mentioned like you said to the growth hormone you know analogs or you can end up with with maybe other untour side effects you're not even aware of so what are the kinds of things that people should be wor worried about or concerned about with with peptides well I think in general peptides are generally very sof safe um and efficacious the ones that are concerned of the growth hormone releasing peptides um and uh m c I did see one person that's for the mitochondria to for better energy I've had one with anaphylactic and I had another doctor friend he's a co-founder of clinical peptide Society uh he also saw one anaphylactic reaction so just got to be careful they they're rare um side effect but you know medications like you know even taking you know a you can get ANC so yeah know I agree I guys taking aspirin you almost bled to death in his stomach so yes yeah um so the the uh this field is is really just exploding but at the same time um there's a lot of push back from you know the government and the FDA to try to regulate these in ways and and one of the things that sort I caught earlier that you said which which uh got my attention was that there's not a lot of human clinical trials a lot of the data you're talking about his animal studies

33: 00 you're talking about his animal studies uh well not all peptides um one of the peptide I just uh published was on thus off one um and it just it's open access um so you can find it it's the comprehensive review of the safety and efficacy of thymus alpha 1 in human clinical trials so there's 11, 000 U patients worldwide that have been in on human I mean clinical trials on time C for one and basically it's been safe I I mean no efficacy based on the St yeah I mean efficacy most of them basically improved I mean they were doing studies like he B he C now there's newer drugs and all that but back then they had nothing so they were using thus Alpha One and for chronic Hep and this is like interesting if you look go back in history and you're reading it and it's like well you know there's better ones here now but yeah yeah well I remember seeing in China during Co there studies on T1 and on Co treatment and some studies shows reduced mortality un the one compound pharmacy got this whole peptide upset with the FDA and it was the compound pharmacy advertised that there's a cure for covid oh wow and then you say cure to the FDA with covid yeah oh you're going to be shut down that's why they were upset so that that's was one of the reasons why it's on the ban list but it has been approved as an orphan drug in the 70s and when children they the first clinical trials were children born without THS glants and they they even FDA goes let's get this going let's see

34: 30 FDA goes let's get this going let's see if we can help these children and they all it was remarkable it saved their lives yeah so this is before th one the precursor of it but anyway it's just like hey it's safe it's around it's it so that's why I wrote the paper to basically um show it to these attorneys who are going to eventually um follow law against FDA about this yeah well it's it's a whole problem often you know we find it supplements or things that really work well tend to be regulated in ways that are confusing to me because they work they're safe there's a long history of use there's plenty of evidence uh and they're bioidentical compounds or things that the body makes or uses and and I just find it sort of striking that you know maybe I I don't want to be conspiracy theorist but you know there's seems push back maybe from Pharma to to kind of try to reduce access to certain compounds because they work too well that's well I you know I I have theories there too but but uh anyway I I just really want for people out there especially your group is to get on to save peptides. org and um hopefully you'll have that on your podcast there and just it's really quick to sign the petition send it to your friends and family uh we need more signatures and uh it's Grassroots and I go on every lot of radio shows and podcast and we get a little blip after the podcast that's great yeah I think it's important Edwin say is important you know we we want to be able to uh have access to compounds that can

36: 02 to uh have access to compounds that can support our health and we have to be they have to be used judiciously they have to be prescribed by a physician you have to be under someone's care who knows what they're doing but in that context they should be available to be used and what's happening now is a restriction on that use so if you go to save peptides. org. com. org save peptides. org you can basically sign a petition and and that will help to the FDA to perhaps reduce their their restrictions or potential ban they're not banned yet there's a proposed ban so I think we're we're going to still see it's being fought there's a lot of legal cases going on about this um in terms of a few other use cases you know one of the things that that happens as we get older and often a big problem for people is energy we lose energy uh and uh one of the fundamental things that happens as we get older is our mitochondria don't work as well we don't produce energy from food and oxygen as well so basically our engine starts to slow down um and and we see you know obviously see a 2-year - old running around bouncing up the walls and you know full of energy and you see like a 92y old and they're moving super slow and a lot of that has to do with mitochondria yeah dysfunction is huge so so talk about why the the importance of mitochondria and what um what the use of peptides are in helping to improve the function and health of the mitochondria how they work uh so as you mentioned um uh mitochondrial function is critical for Optimal Health and uh I we check in

37: 33 for Optimal Health and uh I we check in our office uh NAD levels um so I say Nancy Apple dog because it's nicotinamide ad me not something you can really check easily at a regular lab so you use a special lab yeah it's gfinity lab gfinity it's a finger uh finger stick um and it's j i n i fi t y okay we'll put that in the show notes everybody but J Infinity lab to check your NAD levels is that and you can order yourself you have to go through your I think you can order yourself um and basically you it's it measures your white blood cells uh intracellular NAD levels so uh it's a fingerprick test there's like uh five whole circles and if we draw your blood a little extra we'll just put it on this and we let it dry and there's the little droppers you have to do but we send it in in bulk rather than one at a time cuz things get lost in the mail so anyway but the thing is that wife's NAD level was low it was uh um anyway 20 not optimal and I was 30 a little better but uh I always had more energy than my wife and um so I told her let's try this product that has n MN so I tell my patients like Nancy Michael Nancy it's it's stands for big chemical work but it's a precursor of NAD so a month later we rechecked and she went from 20 to 40 I went 30 to 50 amazing and it's amazing cuz I like to ride uh I'm not a professional cyclist but U

39: 00 I'm not a professional cyclist but U anyway I like to ride with younger people keep up yeah try to keep up then did you do oh yeah I mean there was a group ride they go oh you're so young I go no I have higher NAD level so this is like the enhanced Olympics then right exactly so you know what all the athletes are taking NM to to improve their energy but you can measure it and the second thing I mean that's not a peptide no it's a supplement that fda's now banned on uh since March of 2023 against Amazon it it was available for over 10 15 years David Sinclair yeah it's still available but it's through physicians's office but not on Amazon so it's harder and harder but I think David Sinclair is making a drug so it's a shame it's it's natural product exactly so anyway so so n but you're talking about how to optimize even n ad with another peptide no it's not a peptide it's it's a B vitamin but the other thing is what I'm trying to do in conjunction with that yeah is that um you got to optimize sleep too so I think epien can help with better sleep and you get your REM up and you know a lot of people have drenal fatigue so you got to get that uh deep sleep REM sleep up and get good good quality sleep so it's not quantity it's also quality but um anyway there is a peptite since we're talking about pepti uh m o TS c m c it's a mitochondrial pepti and it just basically turns on the mitochondria work faster and uh for when I've tried it um

40: 31 faster and uh for when I've tried it um the first dose is like okay feel good second time I tried it I was like and third time was damn this is great so is it something you use every day longterm I do it intermittently so U but I you know there's so many different compound fores that make it um and the problem is I I'm a whis when it comes to injection and if it burns I don't like the burn yeah and the the on that I would us it never burnt and then we they don't they got stopped Taylor Made You Know stopped making it yeah and we had to go elsewhere and I just so I prefer IV pushes if I get an IV of nutrition I'll say do a MSI push doesn't burn at all and feel gross but I do it interventionally cuz most MSI Burns and I'm a Wim was I mean I I can go in cold water I love cold plunge but I don't like to burn could you use it every day if if well you're supposed to you can do the protocols 10 milligrams once a week or 5 milligrams sub Q twice a week um you could go a little further if you have an event like you're trying to like yeah run faster like you have a marathon coming up or something like that but in general just uh once to two times a week and and are there any risk to it well one like I said before um I did have one patient that developed anapat reaction and she was she thank God she was by she lived by herself but she had a where thought to basically knew something was wrong so

42: 01 to basically knew something was wrong so she was in Arizona she ran outside thank God her neighbor was there she said call 911 and she collapsed outside wow um and then she basically like a month later goes can I try it again no right never um but she goes I lost so much weight it's so good so that's another benefit with Moy it helps the weight loss yeah speeds up metabolism yeah um white fat to Brown fat too so it's increases energy production and burning right so increases your metabolism literally the other there's a few other mitochondrial peptides like ss31 and human in can you talk a little bit about how those work what they do how they're used yeah SS yeah so ss31 is another interesting uh mitochondrial peptide that can help I kind of explain to my patients that uh um you know as you get older it's like your underwear you wear that same underwear over time you lose that elastic um so your mitochondria gets weak and and ss31 kind of snaps it back in place so then the basically the when you know the electron chain uh where you produce all the ATP and energy basically it's better form so if the confirmation of the mitochondri doesn't work it it gets weak then that's why your production gets weak so it doesn't speed up the mitochondria but it helps busy their structure exactly what about human in I haven't used that yet

43: 30 about human in I haven't used that yet have you a little yeah a little okay uh so I think there's a I mean there like you said there's 300, 000 I don't know how many I always I get on podcast and always someone wants to stop me goes what about blah I never heard yeah and then they'll go one hour talking about it giving me electric yeah yeah so yeah I don't know all of the peptides so so the question really is is you know when you're you're seeing a patient um and we talked a lot about you know peptides where everything's going to be in the show notes here so people can learn more about them we're going to put links to uh the studies you mentioned we're going to be links to save yeah um and if you can donate too that'd be great it's try to get a phase one clinical trial for bpc157 yeah so you got a few million dollars to do some research I don't think it's Millions but just no it's important and I think you know even $ 20 will the more research that we have the better off we're going to be to understand these but but they are kind of excit exciting new therapeutic in medicine that I never really learned about except insulin and and I think that um it help across a range of human um functions that tend to decline as we get older so they seem to be sort of an adjunct in longevity and a lot of people in the longevity space are using this you know what are your sort of top longevity peptides well number one's that be that one you mentioned twice a year 10 days reset right the pineal gland exactly okay got it and in terms of the um you know the kind of um

45: 03 um you know the kind of um use second would be th off one for your immune system yeah those two yeah so there's some like there's some Heavy Hitters there's some Powerhouse peptides that are kind of go-to for you that are part of your standard practice but when someone comes in to see you H as a patient you take their medical history how do you sort of begin to think about you know which are the right peptides for each person and how long to use them and how to give them and it's it just seems like you know we don't really learn how to do that in medicine well uh what I do is uh when a patient comes to see me we actually it's a pretty extensive um morning visit when they come and uh we do so many different testing we're looking for DNA damage we're looking at your genetic Snips uh and U we're also looking at leaky gut um we're looking at many different things that most conventional doctors um don't check uh like o oxidative stress protocol to see if you have um cell membrane damage um and so anyway the thing is um we I have this Foundation triangle of health and a lot of people have different versions of it but it's hormones leaky gut fix your liver remove toxins um sleep exercise and then in the middle is nutrition so I nutritional so try to get that balanc and then later add peptides I don't do that first I mean unless so like phase two yeah two or three just add more or

46: 30 yeah two or three just add more or something like that but unless they have an acute injury it's like okay let me inject and so their immune systems down or theyve got an injury there things you'll pull out so occasionally I'll pull out but generally I we do a biological age too on all our patients so um anyway I look at the intrinsic age and later I have to tell them you're older than your chronological age or younger and uh they always say how do I get it better so I'm publishing another paper uh and I just don't have time just but we submitted uh a paper to be and it's being reviewed and uh I'm trying to get that open access quickly and uh so it's an interesting thing I'll just tell you Alzheimer's patient 80 years old could not finish a sentence and in a year his cognitive test significantly improved he started 2% he was like failed yeah and now he's trading stocks he said and uh his biological age reduced by eight years in a year and it's telling me was increased the size but is he making money on the trading stock yes but the beauty I'm not going to tell you what the protocol is but uh wait the paper because the paper has to be published first I don't want to curse like oh no okay next time okay we we'll link to it eventually in the show notes I'm dying to know what that protocol was because you're talking basically about reversing cognitive decline using um I know I I'm really excited about that X price because I think I'm going to submit it this is just one case yeah but

48: 00 submit it this is just one case yeah but I have other cases yeah oh I have several yeah I I am busy in my practice do you want to maybe um share also a little before we get into sort of some of the case studies do you want to share a little bit about the the peptides related to sleep because there's there's a number of peptides that can help and impr sleep and there's 70 million Americans who have some type of sleep disruption trouble falling asleep staying asleep I think the best one honestly I'll just start with that there are other peptides there but uh I mean I've used dsip Delta sleep inducing peptide and Ryan Smith and I we were doing at the same time texting oh my God my sleep's so good you know because we both struggled with sleep but then eventually stopped it was like tacki flaxes to stop working yeah and we were doing it every day and then figured we have to put it back down to like three times a week or something like that and then that's dsip yeah I stopped using that um Epal is phenomenal EP over time you you're because you're generating um you're turning on three genes for melatonin production so it's phenomenal so over time you're not going to require some sleeping I have people that are saying OMG I am sleeping great so that's your top but it took me three years because I was doing it twice a year and then on the third year I was doing it just to get my biological age down yeah that's amazing are there any others that are helpful for sleep uh CJC 1295 when I first took it I

49: 30 uh CJC 1295 when I first took it I forgot that uh it burns like you not burning injection but you you feel like you're on fire and I remember injecting and um it's worse if you drink alcohol if you have wine so I had wine and then I injected and I felt like I was on fire but I was a little drunk so I fell asleep quickly but I had a brief moment of empathy women going through hot through menopause I'm getting hot flashes because it's like if this is a hot flash just shoot me because I can't survive yeah this is terrible yeah so but then I slept like a baby so is that something is this something every day CJC 5 days a week five days a week you don't want to burn out the P so I I have a pepti class we teach healthc care providers and I have a class March 16th it's almost sold out but no is this a curriculum is this a something that a healthcare provider would sign up for and is it a multipart course that's a one day introduction to peptides but we teach seven new peptides that's um case the FDA takes things out so um and um anyway it's exciting it's on clinical peptid society. com if you're interested I'm a co-founder of it it's going to be in Orlando March 16th um so it's an in-person seminar yeah inperson not zoom I had someone from Beverly Hills uh sign up and they go I thought it was Zoom it's like it says right there so person zo the website against clinical peptid society. com I I'm a co-founder of clinical TR decided we're going to put that in the show notes if you're a practitioner you want to learn more

51: 00 practitioner you want to learn more because it's hard to learn about this stuff yeah you're you're actually I remember you called me once what the hell about these peptides you know what Mark said he goes uh teach me peptides in five minutes I said Mark I can't do that just read my book he goes I don't want to read the book give me the G Che I wanted the g - so I mailed him the book and you read it and you're really good I'm like watching you it's like I'm learning hi I'm learning I like I'm a sponge I like to learn his uh so we me in five minutes this like my life it's true not fair but I was looking for because it's hard to get is like a cheat sheet okay here's the dose of the peptides here's the frequency of the peptides here's the use case here's how to mix them up here's the amount of units you get we teach that in the class and then we we do offer like Essential Knowledge it's not a certification Essential Knowledge of of clinical use of peptid so you have there's a test and uh there's 0 certification kind of thing yes but we don't call certification we call Central knowledge yeah because we worked with uh AMG Age Management medicine group we would love for you to come and speak there sure yeah I think this is such an important I'm the planning committee okay got it I got you're giving me a pitch now to go give a talk I hear you I'll be in November it's in some place fun and beautiful no definitely an option um it'll be Utah Utah oh my daughter lives there oh Salt Lake uh I don't know exactly one hotel okay Park City that's

52: 30 exactly one hotel okay Park City that's close enough to Salt Lake close close Okay uh so that sounds good the the other thing I I kind of want to hear from you you know is um you know there's an issue around cost right these are not cheap right and so you know people might be listening get excited about it want to try it and then they go look it up and it's like so expensive well what's expensive it's all relative I mean so I mean some patients um it's it's investment of their life and their health and um I have people of all different backgrounds and uh when it comes to their health though I mean it's like there's not many Alternatives when you come to see me you usually failed everything else right everything else and uh so it's hundreds of dollars sometimes for I mean but the thing is it's trying to get you from A to B and uh and then over time you know if you use it sparingly it's not yeah so they're sort of like kind of fix things and get you healthy and then you can use them as sort of Maintenance intermittently if you lose weight or you know things get better and you know so it's a I give you the path to to get well yeah it's up to the patient to follow the path yeah and I'll always be in business because they usually fall off the path there you go never short a lot of my patients do they they I'll try better yeah now if we do a good job in fixing the food system and maybe uh dealing with a new way of thinking about chronic we might have a reduction business I hope but uh there's going to be sick people for a long time

54: 01 going to be sick people for a long time um in in terms of uh case studies oh can you share a few kind of highlights from your career you mentioned the Alzheimer's case you mentioned your son with it B you mentioned yourself a few times i' I've certainly had a few positive experiences myself patients well um I've had one woman who slipped um chasing her grandchild on carpet and her shoulder pock out uh got worked up and they said you need a shoulder replacement uh so she um uh said I want a second opinion and she drove like two hours to see me she used to live closer but she wanted to see me um and she had five tears in her shoulder uh super spinatus infraspinatus uh the lbum tear and and two other tear so I said with let's let me inject with ultrasound guidance and she could not even put deodorant underneath her arm she could not wow that she was limited she but she didn't want to have surgery because uh she wanted to try this alternative way and there was no one to take care of her yeah her husband passed away so she didn't have anyone to help her after Soldier surgery yeah so um each month she came once a month and have total five times um her movement at with these peptides I used bpc and thymus and beta 4 uh that's it no stem cells no exosomes no growth factors just peptides uh just

55: 30 no growth factors just peptides uh just I knew where the tears were and I basically injected there and um each month it just got better by the third month it's like you know she's you could see significant Improvement by the fifth month I I was telling her I probably had to inject your good shoulder CU you're going to realize your uh the damage shoulder is um going to get so well so a year later I mean she did come back she goes you know my good shoulder I mean the one that you injected feels like it's super young and she likes the golf she goes you got to fix my other SCE that's amazing so it's amazing yeah I mean it's regenerative and I gave a talk uh you just gave her once a month in the joint bp157 and tb4 so I I gave a talk um to traumatic brain injury to Mark cordon's uh um U Workshop to healthcare providers and well I was talking about peptides to help the brain and um I kind of got off label and was talking about um some of these interesting cases and there was a retired Air Force Orthopedic uh he was like a captain in in the Air Force and he got up put his finger in my face and he was at he goes damn you you're going to ruin the orthopedic careers and I say yes Me by myself is going to ruin all these orthop no you can be educated and offer this to your patients course so I'm excited there is a uh a doctor that graduated from um Dominic Republic and he found me and he goes let's I want

57: 01 and he found me and he goes let's I want to become an orthopedic surgeon and I need to get something published and my dad's an orthopedic surgeon and it's like in Miami it's like oh so we would been talking we have two clinical trials he needs to get IRB approval I go I don't need IRB approval yeah I don't have anything to prove but I think for your future career you should get IRB approval yeah uh and I told once some s can go to and uh hopefully we can get this quickly improved and start the study that's amazing because one is we're going to do MRI be you have before the knee injury like ACL and then uh do a month into the knee uh for like three times like once a month for three times and then in six months repeat their MRI because I did a study published and it was a subjetive people we call and say do you feel better but orthopedic surgeons want to see like for example heal a meniscus that's torn yeah my mother had a partial meniscus tear and I actually I I flew to Pennsylvania uh cuz she was getting I couldn't figure out how bad it was and when I saw the airport it was like oh Houston we have a problem she couldn't even turn like 180 it was like just really slow and um so when I got home I've been in I injected her and then did it have to go in the KNE joint or just in the joint it has to be in the joint yes you could try around but the best is in the joints it's easy

58: 31 but the best is in the joints it's easy to I mean anyway uh for me it's relatively easy yeah but the thing is that uh I injected like then later like that was October and then Thanksgiving I was there injected so I flew back to Pennsyl and then Christmas time I injected her and I mean Christmas time she didn't need a third injection but she goes since you're here just inject me so my mother is now a peptide junkie and for ostearthritis too would it help yes it can help with yeah and they did studies in animals with arthritis they induced arthritis in the paws and G bpc and it has reduced the does it regrow cartilage I think you to regrow you do need for stem cells yeah stem cells so so last thing I want to sort of just touch on you know the sourcing and and finding peptides and finding practitioners and safely doing this because it's a bit of a wild west out there so people are getting it off of unregulated websites and you know you don't really know what you're getting and and there's not really there's risk to it so so how one how do you sort of um you know find the right practitioner and and use the right compounding pharmacies uh to find the right peptides well on our uh clinical peptide Society we do have um practitioners who've taken the quotes um they passed their test they had training they have training so um anyway they they basically have the central knowledge on how to use peptides and they basically do a lot of peptides in their practice so you can look at per

1: 00 their practice so you can look at per state where they are located um and U anyway uh I don't know all the doctors in in America or but I do know some people that I I deal with but we usually I mean there's only about 20 compound phes that are 503a that produces uh sterile inject 503 me it's like it's good for human use and it's regulated by the FDA exactly State inspected and all inspected and and you can be confident in the compounds that are coming from and they they check for uh basically third party inspection for uh basically any uh mold or bacteria you list those on clinical peptid society. com I don't even know all the 20 I have several but we use but I don't know all 20 I mean to me I know most of them but don't know all of them but I don't list it all there but I will give you a personal list what I use so but so basically you have to find someone who's understands the science behind it who knows how to use them appropriately for example you're you're sharing is you know some of these you only take for 10 days twice a year some of them you take you know you take periodically or love you take my class yeah I can get you the next level okay great I'm coming so I I think this has just been such an enlighting discussion I think you know people can learn more about uh your work by going to clinical peptides soy. com definitely sign the petition say peptides.. org and of course you can check out uh Dr Lee's books uh the Fountain of Youth with

1: 01: 31 books uh the Fountain of Youth with peptides and his new one called uh is that the one that's the newest one yeah so this has really been fabulous conversation I've learned a lot and I think uh well not everybody can easily access these compounds uh it's something to kind of explore particularly if you have certain conditions and issues that that really respond well to this so we talked about and not all peptides are injectables there are peptides that you can take my mouth so or orally and uh there is a booth here uh at this uh show called health jevity and it's only through doctors um so they have an account with HTH jevity um I'm kind of helping him well uh kind of with with that Journey so we're kind of um I get no Royal really helped the gut healing like bp157 another so yeah I he some pretty cool products there well thanks for dedication in this field for educating all of us for writing the book for teaching the courses for fighting the fight against the FDA I really appreciate I feel like I have swag up the mountain yeah well thank you so much for what you do and hope everybody love listening to this podcast and thanks for pharmacy yes thanks pleasure if you love that last video you're going to love the next one check it out here