Biohacks, Ranked by Evidence

A physician stress-tests the most popular recovery and longevity practices against actual evidence — cold exposure earns its place near the top.

Doctor Ranks Popular Biohacks: Best to Worst

A physician ranks popular biohacking practices by evidence quality—where does cold exposure land on the spectrum?

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Doctor Ranks Popular Biohacks: Best to Worst: Full Transcript

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Today I am ranking the best and worst biohacks from F - tier dumpster fires all the way up to S tier. You actually live longer. Some of these biohacks are great, some are eh, and some should come with a warning label that just says made by a guy named Trevor who definitely failed high school chemistry. And where else to begin but the bottom, the F tier. This is basically the net negative

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TikTok. Just go ahead and skip it. Next up, Simaglutide for healthy people. What is it? It's a GLP-1 drug for diabetics and obese patients. Now used by dudes who want to lose the last 8 lbs for vanity. Why is it F tier? Well, because of the side effects. It can remove muscle, slow gastric emptying, and fix a problem that you don't actually have. This is like going on chemo because you have a pimple. This stuff works. Also

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mitochondria. Why is it Dtier? Well, the early research is promising, but way overhyped online. This is the shiny blue toy of biohacking. The science is barely walking and people already want it to run marathons. Some early evidence that it can reduce oxidative stress and can provide some possible cognitive support. Seems people do it mostly for the tick - tock blue tongue and to gain some cloud as being on the forefront of longevity.

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stem cell therapy. Usually sold by anti-aging clinics. What is it? IV stem cells marketed as full body regeneration. Why is it Dtier? Well, great for cancer patients, not amazing for feeling younger. If stem cells fixed aging, Jeff Bezos would already be 18. Lots of money to be made in this field. Definitely not a fountain of youth. Keep moving. Next up, mega supplement stacks. What is it? Taking basically 15 to 30

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It's basically walking barefoot on the ground to absorb Earth's electrons like trying to charge with USB grass. Why is it Ctier? Well, that's because there's lowquality studies on it. There's really big claims and the effects are not so apparent. Reality, there is probably more to it that we can't or haven't measured yet. It makes sense that humans are meant to live in close contact with nature most of the time with our bare

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focus. Why is it Ctier coffee? Great. Nicotine, I wouldn't recommend starting it for focus. Coffee is your supportive best friend, whereas nicotine is like the ex who keeps texting you at 2: 00 a. m. Don't overdo it if you're going to do it with either one. All right, next up, hyperbaric oxygen therapy. What is it? It's breathing oxygen under pressure to increase tissue oxygenation. Why do I leave in CER? Well, it's actually very

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that there is no real data. That's basically it. Let's move on to the B tier. Helpful, solid, but probably not magic. Translation. These won't change your life, but they will probably improve it. And the first one up is breath work. What is it? Controlled breathing techniques to regulate the nervous system. Why is it Btier? Well, proven HRV and stress improvements and studies. It's basically meditation for

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merit to it, but we need more data to back it up. Give it a try. See how it works for you. Next up is mitochondrial stacks. Things like PQQ, CoQ10, Spermadine, things like that. What are they? These are supplements designed to support cell energy and repair. I leave them in the B tier because there is some good evidence to support them in specific groups. Otis effects and others. Think of these as like I don't

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TRT is life-changing for the right guy. For the wrong guy, it's just roids. The problem here is that TRT became very popularized due to marketing. And as always, a lot of people behind it making lots of money. Reality is that most guys with low tea have low tea not because of some intrinsic issue causing hypogonatism. It is usually because of their lifestyle. If they would commit to cleaning up that

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of 175 to 200 ° F for about 15 to 20 minutes five times per week. Now, traditional saunas can cost a lot of money, but there are other options out there. You can get similar benefits from IR saunas, which tend to be less money, steam saunas, which there's a couple out there that are very cheap, and hot tubs even. It doesn't matter the modality. It has to do with getting the core body temperature up a couple of degrees.

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you can do for your health and longevity. Period. So, anything you can do to make it better is probably worth it. If you already get great sleep without any of these adjunks, then you don't need them. If you get sleep despite good sleep hygiene, give them a try. Next up, GOP1s for obesity and diabetes. What is it? These are medications like Ompic and WGOI and all of the other brands that have popped up

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low carb that induces ketosis. Why is it a tier? It does show huge improvements for diabetics and insulin resistant individuals. This does work. You will lose fat. However, it is not sustainable for most people. That's the major drawback of it. I don't have a whole lot else to say. If you want to lose fat fast, it's great. I've done it myself. It can be a tough road, though. Some evidence suggests that animal proteins

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me. Less chance of injury, better chance of recovery from injury and illness. It is one of the best predictors of longevity. So, start lifting weights. Except daily movement, things like walking. What is it? Well, 8, 000 plus steps and regular lowintensity movement. I put it in the S tier because there is massive reductions in heart disease and metabolic dysfunction shown in studies over and over again with hundreds of

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Doctor's orders. Even 5 to 10 minutes. Even if it means pretending like you're taking a big dump and holding up in the bathroom for 20 minutes if you need to. Yes, that's my go-to. All right, next up, social connections and finding your tribe. Basically, meaningful relationships and community support. Why do we put it in the S tier? Because it's one of the strongest predictors of longevity more than almost any other

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Key Insights

cold exposure ranks high: strong evidence, low risk, accessible

Compares favorably to expensive interventions with weak evidence

Free/low-cost with established physiological mechanisms

Best practices: gradual progression, consistency, medical clearance when indicated

"The body adapts to what you consistently demand of it—controlled stress builds resilience when applied deliberately."